{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:51:59Z","timestamp":1761918719254},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:00:00Z","timestamp":1114128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To report new recommendations for the primary care management of dyspepsia without alarm signs in England and Wales.<\/jats:p><jats:p><jats:bold>Method<\/jats:bold> :\u2002An independent, representative group of health care professionals, patient representatives and researchers developed the guideline using evidence\u2010based and small group\u2010working principles, and incorporated extensive peer\u2010reviewing and feedback from stakeholder organizations.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Referral to investigate dyspepsia should be made for alarm signs and not on the basis of age alone, reflecting the balance of benefit and harm from endoscopy. Empirical management without formal diagnosis is appropriate for most patients: reviewing patient history, lifestyle, over\u2010the\u2010counter medicines, and providing a course of proton\u2010pump inhibitors and\/or <jats:italic>Helicobacter pylori<\/jats:italic> test and treatment. Patients with ongoing symptoms require at least annual review to discuss symptoms and lifestyle, and as appropriate, encourage stepping down prescribed medication and returning to self\u2010care. A new strategy included in the step down process is the use of therapies \u2018on\u2010demand\u2019.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002The guideline provides structured and supported recommendations for both undiagnosed and endoscopically investigated dyspepsia. Some favour increased investigation to detect Barrett's oesophagus and carcinoma. However, there is inconclusive evidence that patients without alarm signs will benefit subsequently from endoscopy, while investigation involves a small but real risk of harm.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02445.x","type":"journal-article","created":{"date-parts":[[2005,4,23]],"date-time":"2005-04-23T00:34:58Z","timestamp":1114216498000},"page":"1135-1143","source":"Crossref","is-referenced-by-count":18,"title":["Managing dyspepsia without alarm signs in primary care: new national guidance for England and Wales"],"prefix":"10.1111","volume":"21","author":[{"given":"J. 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