{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:23:20Z","timestamp":1776356600655,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To compare endoscopic banding ligation vs. no treatment in cirrhotics with intolerance or contraindications to <jats:italic>\u03b2<\/jats:italic>\u2010blockers for prevention of first bleeding in portal hypertension.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002A sample size of 214 was planned with all sizes of varices. However, the trial was stopped due to increased bleeding in 52 patients in the ligation group. The baseline severity liver disease and endoscopic features were similar. Ligation group: 25 (M\/F\u2003=\u200321\/4, mean age: 60\u2003\u00b1\u20039.37\u2003years); 27 not\u2010treated group: 27 (M\/F\u2003=\u200317\/10, mean age: 63\u2003\u00b1\u200310.27).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002The mean follow\u2010up period was 19.5\u2003\u00b1\u200313.3months: five bled in the ligation group (20%), three from varices (two after banding at 11 and 17\u2003days; one during the procedure), and two from gastropathy; two bled in the not\u2010treated group (7%\u2013 two both varices) (<jats:italic>P<\/jats:italic>\u2003=\u20030.24). There were seven deaths in the ligation group and 11 in the not\u2010treated group (<jats:italic>P<\/jats:italic>\u2003=\u20030.39).<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002Sixty per cent of the bleeding in the banding group was probably iatrogenic, requiring the study to be stopped. Endoscopic banding ligation was no better than no treatment. This study suggests that ligation may be harmful when used as primary prophylaxis, similar to prophylactic sclerotherapy in the past.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02457.x","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T11:23:20Z","timestamp":1118316200000},"page":"1435-1443","source":"Crossref","is-referenced-by-count":44,"title":["Primary prophylaxis of variceal bleeding in cirrhotics unable to take <i>\u03b2<\/i>\u2010blockers: a randomized trial of ligation"],"prefix":"10.1111","volume":"21","author":[{"given":"C.","family":"Triantos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vlachogiannakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Armonis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Saveriadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kougioumtzian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Manolakopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tzourmakliotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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