{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:36:07Z","timestamp":1755599767870},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The protective role of <jats:italic>Helicobacter pylori<\/jats:italic> in gastro\u2010oesophageal reflux disease has been widely discussed.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To assess the risk of reflux oesophagitis in patients with functional dyspepsia after treatment for <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002A randomized, placebo\u2010controlled, investigator\u2010blinded trial was carried out on 157 functional dyspeptic patients. Patients were randomized to receive lansoprazole, amoxicillin and clarithromycin (antibiotic group) or lansoprazole and identical antibiotic placebos (control group). Upper gastrointestinal endoscopy was performed at baseline, 3 and 12\u2003months after randomization. The primary aim was to detect the presence of reflux oesophagitis. Analyses were performed on an intention\u2010to\u2010treat basis.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002A total of 147 patients (94%) and 133 (85%) completed 3\u2003months and 12\u2003months follow\u2010up, respectively. The eradication rate of <jats:italic>H. pylori<\/jats:italic> was 90% in the antibiotic group (74 of 82) and 1% (one of 75) in the control group. At 3\u2003months, reflux oesophagitis was diagnosed in 3.7% (three of 82) in the antibiotic group and 4% (three of 75) in the control group (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.2). At 12\u2003months, diagnosis was established in five new cases within the first group and in four within the second (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.2). No difference was found in heartburn symptoms.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002<jats:italic>H. pylori<\/jats:italic> eradication does not cause reflux oesophagitis in this western population of functional dyspeptic patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02461.x","type":"journal-article","created":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T11:13:08Z","timestamp":1115637188000},"page":"1231-1239","source":"Crossref","is-referenced-by-count":19,"title":["<scp>Helicobacter pylori<\/scp> eradication does not cause reflux oesophagitis in functional dyspeptic patients: a randomized, investigator\u2010blinded, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"E. 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