{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T16:43:54Z","timestamp":1695833034756},"reference-count":32,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The epidemiology and pathophysiology of non\u2010erosive gastro\u2010oesophageal reflux disease differs from erosive gastro\u2010oesophageal reflux disease. There is a possibility that non\u2010erosive gastro\u2010oesophageal reflux disease treatment requires a different regimen\/approach but it is not yet acknowledged.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To investigate the efficacy of famotidine and omeprazole in the treatment of gastro\u2010oesophageal reflux disease, especially non\u2010erosive gastro\u2010oesophageal reflux disease.<\/jats:p><jats:p><jats:bold>Patients and methods<\/jats:bold> :\u2002A randomized, open\u2010label trial was conducted. Fifty\u2010four gastro\u2010oesophageal reflux disease patients were assigned to treatment with famotidine at a dosage of 20\u2003mg twice daily; or omeprazole, 20\u2003mg once daily, for a period of 8\u2003weeks. The Short Form\u201036 Health Survey and Gastrointestinal Symptom Rating Scale administered at baseline and after 8\u2003weeks of treatment as well as a symptom questionnaire were conducted daily.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Short Form\u201036 revealed that gastro\u2010oesophageal reflux disease has severe impact on health\u2010related quality of life. Thirty\u2010nine subjects (77%) were endoscopically diagnosed as non\u2010erosive gastro\u2010oesophageal reflux disease. The mean Gastrointestinal Symptom Rating Scale abdominal pain, and indigestion score of non\u2010erosive gastro\u2010oesophageal reflux disease significantly improved in famotidine\u2010treated patients (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), but not in the omeprazole. There was no significant change regarding improved heartburn symptoms of non\u2010erosive gastro\u2010oesophageal reflux disease between treatments in the daytime or night\u2010time.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002Famotidine and omeprazole were both effective in improving symptoms of gastro\u2010oesophageal reflux disease, particularly non\u2010erosive gastro\u2010oesophageal reflux disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02467.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:51:18Z","timestamp":1119196278000},"page":"2-9","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of famotidine and omeprazole in healing symptoms of non\u2010erosive gastro\u2010oesophageal reflux disease: randomized\u2010controlled study of gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"21","author":[{"given":"T.","family":"Wada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tanida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Togawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Joh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.2008.S1"},{"key":"e_1_2_5_3_2","first-page":"125","article-title":"A statistical evaluation on the age and sex distribution of basal serum gastrin and gastric acid secretion in subjects with or without peptic ulcer disease","volume":"33","author":"Tahir H","year":"1984","journal-title":"Hiroshima J Med Sci"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8612992"},{"key":"e_1_2_5_5_2","first-page":"959","article-title":"Helicobacter pylori infection is the major risk factor for atrophic gastritis","volume":"91","author":"Kawaguchi H","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02131.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00009-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00012-1"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750026697"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698230"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00095-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535722"},{"key":"e_1_2_5_14_2","first-page":"41","article-title":"Quality of life in reflux and dyspepsia patients. 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