{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:24:09Z","timestamp":1746339849710},"reference-count":19,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The treatment of functional dyspepsia is controversial.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002The purpose of this paper is to clarify the initial effect of prokinetic, acid suppression and antianxiety treatment for functional dyspepsia patients.<\/jats:p><jats:p><jats:bold>Patients and methods<\/jats:bold> :\u2002Sixty\u2010four functional dyspepsia patients without <jats:italic>Helicobacter pylori<\/jats:italic> infection were randomly assigned to 15\u2003mg\/day of mosapride, 40\u2003mg\/day of famotidine, or 30\u2003mg\/day of tandospirone during an 8\u2010week treatment. Individual functional dyspepsia symptoms were evaluated with 4\u2003cm visual analogue scale before and at 2, 4 and 8\u2003weeks after treatment.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Among 64 enrolled patients, 62 completed the study. Within 2\u2003weeks, visual analogue scale score in the mosapride\u2010treated group decreased from 2.29\u2003\u00b10.14 to 1.57\u2003\u00b1\u20030.20; in the famotidine from 2.04\u2003\u00b1\u20030.16 to 1.09\u2003\u00b1\u20030.12 (mean\u2003\u00b1\u2003S.E.). Therefore, there were significant improvements of functional dyspepsia symptoms in mosapride\u2010 and famotidine\u2010treated patients (<jats:italic>P<\/jats:italic>\u2003&lt;0.01). Furthermore, famotidine was significantly more effective than mosapride (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). On the contrary, visual analogue scale score in the tandospirone therapy was 2.23\u2003\u00b1\u20030.20 and 2.13\u2003\u00b1\u20030.22 before and at 2\u2003weeks, respectively, without any significant improvement.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002A treatment regimen of famotidine at 40\u2003mg\/day had a significant favourable effect on the clinical outcome in functional dyspepsia patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02471.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:51:18Z","timestamp":1119196278000},"page":"32-36","source":"Crossref","is-referenced-by-count":29,"title":["Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies"],"prefix":"10.1111","volume":"21","author":[{"given":"H.","family":"Seno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296788"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8612991"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199806000-00022"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750305440"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409092482"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750305459"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087651"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.1.15"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii37"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.1.47"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)02314-5"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70171-X"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30822.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01123.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00410.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.473"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00781.x"},{"key":"e_1_2_5_19_2","first-page":"CD002301","article-title":"Psychological interventions for non\u2010ulcer dyspepsia","volume":"4","author":"Soo S","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01469.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02471.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02471.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:43:50Z","timestamp":1695757430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02471.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":19,"journal-issue":{"issue":"s2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02471.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02471.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}