{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:23:04Z","timestamp":1772770984516,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long\u2010term users of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) in Japan.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To estimate the preventive effect by normal dose, not high\u2010dose histamine\u2010H2 receptor antagonists (H2RA) for NSAID\u2010induced ulcers.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002We designed two different studies to assess the efficacy of anti\u2010ulcer agents in rheumatoid arthritis (RA) in patients treated over a long term with NSAIDs. An investigative survey divided patients into those not taking anti\u2010ulcer agents (non\u2010medication group); those taking mucosal protective agents (mucosal protectant group), H2RA (H2RA group), proton pump inhibitors (PPI group), or a prostaglandin E1 analog (PG) (PG group). The second study compared prospectively the preventive effects of either famotidine 20\u2003mg bd (famotidine group) or lansoprazole 15\u2003mg daily (lansoprazole group) in patients with PU scars.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002The prevalence of PU in the H2RA group was significantly lower compared to the mucosal protectant group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), and the mucosal protectant group was not significantly different to the non\u2010medication group. The prospective study revealed that the PU onset rate of the famotidine group was 8% (1\/13), and lansoprazole group was 15% (2\/13), indicating no significant differences between the two.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002In Japan, normal\u2010dose H2RA is expected to be a new PU preventive treatment strategy in patients requiring long\u2010term NSAID therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02477.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:51:18Z","timestamp":1119196278000},"page":"67-72","source":"Crossref","is-referenced-by-count":11,"title":["Preventive therapy for non\u2010steroidal anti\u2010inflammatory drug\u2010induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled\u2010study of the preventive effects of lansoprazole or famotidine"],"prefix":"10.1111","volume":"21","author":[{"given":"K.","family":"Miyake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shinji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hiratsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tatsuguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Futagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tsukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1001\/jama.1996.03530320046033","article-title":"Consensus conference. 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