{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:53:18Z","timestamp":1771966398543,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The stomach and the duodenum are frequent sites of involvement by diminutive lesions in Crohn's disease (CD).<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To assess mucosal proinflammatory cytokines and chemokines in gastroduodenal lesions of CD.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  <jats:sup>13<\/jats:sup>C\u2010Urea breath test and upper endoscopy were performed in 29 CD patients and seven control subjects, and biopsy specimens were obtained from the gastric cardia and the duodenum. Histology and mucosal levels of IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20108\/CXCL8 and RANTES\/CCL5 were assessed and compared according to the presence of gastric cardial lesion [bamboo joint\u2010like appearance (BJA)] and duodenal lesion (notched appearance, aphthous erosion and polypoid lesion). In 11 CD patients, these procedures were repeatedly performed after administration of famotidine.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>H. pylori<\/jats:italic> was less frequently positive in CD patients than in controls (10% vs. 71%, <jats:italic>P<\/jats:italic>\u2003=\u20030.003). Prevalence of cardial and duodenal lesion was significantly higher in CD than in controls (59% vs. 0%, <jats:italic>P<\/jats:italic>\u2003=\u20030.008 for gastric lesion; 45% vs. 0%, <jats:italic>P<\/jats:italic>\u2003=0.034 for duodenal lesion). There were no differences in IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20108 and RANTES between CD and controls. Duodenal mucosal IL\u20101<jats:italic>\u03b2<\/jats:italic> and IL\u20108 were significantly higher in positive duodenal lesion than in negative duodenal lesion. However, there were no such differences with respect to cardial lesions. Endoscopic findings remained unchanged after administration of famotidine, while there was a trend towards decreases in IL\u20101<jats:italic>\u03b2<\/jats:italic> and IL\u20108 in the gastric cardia.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The pathogenesis of diminutive lesions of CD may be different between the stomach and the duodenum. Famotidine may not have a therapeutic effect on duodenal lesion in CD.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02480.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:51:18Z","timestamp":1119196278000},"page":"85-91","source":"Crossref","is-referenced-by-count":10,"title":["Mucosal proinflammatory cytokine and chemokine expression of gastroduodenal lesions in Crohn's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"T.","family":"Moriyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hirahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/59.5.613"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.2.115"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1021762"},{"key":"e_1_2_5_5_2","first-page":"103","article-title":"Crohn's disease in endoscopic biopsies of gastric antrum and duodenum","volume":"76","author":"Koreliz B","year":"1981","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091305"},{"key":"e_1_2_5_7_2","first-page":"249","article-title":"Duodenal Crohn's disease: an analysis of 89 cases","volume":"84","author":"Nugent FW","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb00870.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010315"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1542\/peds.83.5.777","article-title":"High incidence of upper gastrointestinal tract involvement in children with Crohn's disease","volume":"83","author":"Lenaerts C","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010544"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(96)00063-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70100-7"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.8.1627.1627"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9233"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.2.587"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.1.55"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309090244"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000223"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02304.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409096833"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.609"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023732"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30847.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00001"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70381-6"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237713"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.2.216"},{"key":"e_1_2_5_30_2","first-page":"133","article-title":"Cytokines in Crohn's colitis","volume":"1995","author":"Sher ME","journal-title":"Am J Surg"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350170015"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.10.1385"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709090140"},{"key":"e_1_2_5_34_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0300-5089(21)00794-X","volume":"7","author":"Joffe SN","year":"1978","journal-title":"Duodenitis. 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