{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:09:42Z","timestamp":1697504982355},"reference-count":27,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Recent studies showed that acid\u2010suppressive therapy aggravates corpus gastritis in patients with <jats:italic>Helicobacter pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002The aim of this study was to evaluate the effect of famotidine, a histamine receptor antagonist on corpus gastritis in patients with peptic ulcer disease.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002We enrolled 287 patients, 173 with duodenal ulcer and 114 with gastric ulcer and 100 patients with <jats:italic>H. pylori<\/jats:italic>\u2010positive gastritis as control subjects. Patients with peptic ulcer were classified according to whether or not they received famotidine\u2010maintenance therapy (20\u2003mg\/day) after primary treatment. At the time of endoscopy, biopsy specimens were obtained from the antrum and the corpus. The degrees of neutrophil and lymphocyte infiltration, atrophy and intestinal metaplasia were scored according to the updated Sydney System.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002The degrees of neutrophil infiltration and atrophy in the corpus were significantly less in patients with gastric ulcer or duodenal ulcer than in patients with <jats:italic>H. pylori<\/jats:italic>\u2010positive gastritis (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Differences in the degrees of neutrophil infiltration and atrophy in the corpus between the non\u2010maintenance group and the maintenance group were not significant.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002Long\u2010term therapy with famotidine does not appear to lead to an increase in the incidence of corpus gastritis or corpus atrophy in patients with peptic ulcer disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02482.x","type":"journal-article","created":{"date-parts":[[2005,6,19]],"date-time":"2005-06-19T15:51:18Z","timestamp":1119196278000},"page":"99-104","source":"Crossref","is-referenced-by-count":2,"title":["Effect of long\u2010term half\u2010dose famotidine therapy on corpus gastritis in peptic ulcer disease"],"prefix":"10.1111","volume":"21","author":[{"given":"T.","family":"Kamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sugiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322501"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300061"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00194.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00330.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00349.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1996.tb00027.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809093891"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90344-C"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-3-199408010-00001"},{"key":"e_1_2_5_11_2","first-page":"1401","article-title":"Increase of Helicobacter pylori\u2010associated corpus gastritis during acid suppressive therapy: implications for long\u2010term safety","volume":"90","author":"Kuipers EJ","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.1.12"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341603"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00196.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00370.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00310.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1999.0029900319"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00834.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01105.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.969"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01147.x"},{"key":"e_1_2_5_23_2","first-page":"959","article-title":"Helicobacter pylori infection is the major risk factor for atrophic gastritis","volume":"91","author":"Kawaguchi H","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.09016.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02131.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00335.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409094860"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.111385"}],"container-title":["Alimentary Pharmacology &amp; 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