{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:13:45Z","timestamp":1769948025936,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The polymorphic enzyme cytochrome P450 2C19 affects omeprazole metabolism. This influence on metabolism might affect serum gastrin levels, and safety, during long\u2010term treatment of reflux oesophagitis.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To examine the relationship between cytochrome P450 2C19 genotype and the safety profile of long\u2010term omeprazole treatment.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002A total of 119 Japanese patients with recurrent reflux oesophagitis underwent cytochrome P450 2C19 genotyping prior to receiving daily omeprazole 10\u2003mg or 20\u2003mg for 6\u201312\u2003months, during which adverse event frequency, serum gastrin levels and endoscopic findings were monitored.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002The incidences of adverse events, serious adverse events and adverse events leading to withdrawal did not differ between homozygous extensive metabolizer (<jats:italic>n<\/jats:italic>\u2003=\u200346), heterozygous extensive metabolizer (<jats:italic>n<\/jats:italic>\u2003=\u200353) or poor metabolizer (<jats:italic>n<\/jats:italic>\u2003=\u200320) groups. In all genotype groups, serum gastrin increased during the first 3\u2003months of dosing but stabilized thereafter. No significant differences were seen either in the rate of reflux oesophagitis healing or symptom improvement among genotype groups.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Long\u2010term treatment with omeprazole was well\u2010tolerated in Japanese patients, irrespective of their cytochrome P450 2C19 metabolic genotype, indicating that dose adjustment depending on metabolic genotype is not required during treatment with omeprazole.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02486.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:19:18Z","timestamp":1117754358000},"page":"1331-1339","source":"Crossref","is-referenced-by-count":25,"title":["Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux 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