{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:22:06Z","timestamp":1779358926096,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The usual onset of type 1 autoimmune hepatitis occurs at puberty or around menopause, whereas disease presentation in the advanced age is less often reported.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To assess the clinical, immunological and histological features of Type 1 autoimmune hepatitis in elderly Italian patients.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002We assessed, at diagnosis, the clinical and immunological features of 76 consecutive Italian patients with type 1 autoimmune hepatitis, focusing particularly on a subgroup of 20 patients presenting at \u226565\u2003years (females 95%, median age 72\u2003years, range 65\u201382).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002In comparison with the younger group, at the time of autoimmune hepatitis diagnosis, elderly Italian patients are more often asymptomatic (25% vs. 7%; <jats:italic>P<\/jats:italic>\u2003=\u20030.04), are more frequently positive for antinuclear autoantibodies (95% vs. 52%; <jats:italic>P<\/jats:italic>\u2003=\u20030.0004) and HLA\u2010DR4 (45% vs. 18%; <jats:italic>P<\/jats:italic>\u2003=\u20030.03); among the extra\u2010hepatic manifestations, autoimmune thyroid disorders are prevalent in the elderly group (25% vs. 5%; <jats:italic>P<\/jats:italic>\u2003=\u20030.02). However, no difference was observed in the histological\/biochemical expression of the liver disease and response to immunosuppression.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002In elderly Italian patients, autoimmune hepatitis has typical serological and genetic characteristics, is more frequently asymptomatic, although prognosis and response to therapy is similar to that of younger patients. As a concomitant autoimmune thyroid disorder is common, autoimmune hepatitis should be suspected and investigated in elderly patients with autoimmune thyroid disorder and abnormal liver function tests.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02488.x","type":"journal-article","created":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T11:13:08Z","timestamp":1115637188000},"page":"1273-1277","source":"Crossref","is-referenced-by-count":64,"title":["Clinical features of type 1 autoimmune hepatitis in elderly Italian patients"],"prefix":"10.1111","volume":"21","author":[{"given":"A.","family":"Granito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cassani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. B.","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20539"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.599"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch072"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24227"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(03)00015-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01389.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00017-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.4.289"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/26.6.441"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03782.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260305"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i12.1862"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.16.11.876"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91081-R"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250211"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00274-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000213183"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92547-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018809431189"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.38.7.801"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80453-9"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-16-6-686"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343631"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02488.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02488.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:36:08Z","timestamp":1697193368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02488.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02488.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02488.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}