{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:36:14Z","timestamp":1791016574009,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Postprandial intragastric acidity is not uniform. Postprandial proximal gastric acid pockets have been described in the present study.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To determine the effects of rabeprazole on regional intragastric acidity and proximal acid pockets.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002Ten normal subjects underwent two 8\u2010day oral dosing regimens with placebo or rabeprazole 20\u2003mg each morning in a randomized, double\u2010blind protocol. Oesophago\u2010gastric pH monitoring was performed on days 1 and 8.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Rabeprazole increased fasting and postprandial gastric pH to above 4 in each area of the stomach on days 1 and 8. With placebo, acid pockets were identified at the cardia\/gastro\u2010oesophageal junction in 62 and 50 of 150 pull\u2010throughs on days 1 and 8, respectively. Acid pockets were detected postprandially 3.1\u2003\u00b1\u20030.2\u20135.8\u2003\u00b1\u20030.1\u2003cm below the proximal border of the lower oesophageal sphincter with a mean pH drop from 4.6\u2003\u00b1\u20030.1 to 1.5\u2003\u00b1\u20030.1. Rabeprazole decreased the number of acid pockets to 30 and 27 on days 1 and 8, respectively. Rabeprazole also decreased their length and magnitude of the pH drop.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Rabeprazole increased intragastric pH on day 1 and 8 and maintained an elevated pH during and after meals. Postprandial acid pockets, identified in the region of the cardia\/gastro\u2010oesophageal junction area postprandially, were decreased in number, length and magnitude by rabeprazole.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02489.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:19:18Z","timestamp":1117754358000},"page":"1321-1330","source":"Crossref","is-referenced-by-count":36,"title":["The effect of rabeprazole on regional gastric acidity and the postprandial cardia\/gastro\u2010oesophageal junction acid layer in normal subjects: a randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"21","author":[{"given":"L.","family":"Vo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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Is a PPI a PPI","volume":"99","author":"Lehner JK","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34564-0"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02489.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02489.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:40:14Z","timestamp":1697193614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02489.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02489.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02489.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}