{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:06:24Z","timestamp":1775243184760,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To perform a systematic review on the efficacy of intermittent and on\u2010demand therapy with either histamine H<jats:sub>2<\/jats:sub>\u2010receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn.<\/jats:p><jats:p><jats:bold>Method<\/jats:bold> :\u2002We conducted randomized\u2010controlled trials of non\u2010continuous therapy in gastro\u2010oesophageal reflux disease patients.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Fourteen studies met inclusion criteria. Because of variation in outcome measures statistical pooling of results was not possible. Results were analysed qualitatively. Four studies evaluated intermittent therapy of treatment 3\u2003days a week with omeprazole 20\u2003mg or daily with ranitidine which were not efficacious compared to a daily proton pump inhibitor. Famotidine 10 and 20\u2003mg, ranitidine 75\u2003mg and cimetidine 200\u2003mg were efficacious in five on\u2010demand studies for relief of symptomatic heartburn episodes. In three of four studies, evaluating only non\u2010erosive (endoscopy\u2010negative) gastro\u2010oesophageal reflux disease patients, esomeprazole 20 and 40\u2003mg and omeprazole 10 and 20\u2003mg a day were efficacious using willingness to continue as an endpoint. Lansoprazole 30\u2003mg and omeprazole 20\u2003mg maintained symptom control in 60\u201370% of healed oesophagitis patients.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Intermittent proton pump inhibitor or H<jats:sub>2<\/jats:sub>\u2010receptor antagonist therapy is not effective in maintaining control in oesophagitis patients. H<jats:sub>2<\/jats:sub>\u2010receptor antagonists are effective for relief of heartburn episodes. On\u2010demand proton pump inhibitor therapy may work in a proportion of non\u2010erosive gastro\u2010oesophageal reflux disease patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02490.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:19:18Z","timestamp":1117754358000},"page":"1299-1312","source":"Crossref","is-referenced-by-count":42,"title":["Systematic review: the efficacy of intermittent and on\u2010demand therapy with histamine H<sub>2<\/sub>\u2010receptor antagonists or proton pump inhibitors for gastro\u2010oesophageal reflux disease 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