{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:27:29Z","timestamp":1765700849017},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Characteristic immune profiles have been demonstrated in gastro\u2010oesophageal reflux disease. However, the genetic basis of gastro\u2010oesophageal reflux disease remains unclear.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To investigate whether certain human leucocyte antigen genes are associated with Barrett's oesophagus.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002Asian patients of Malay, Chinese and Indian descent with Barrett's oesophagus (<jats:italic>n<\/jats:italic>\u2003=\u200359) and those without reflux symptoms and a normal oesophagus (<jats:italic>n<\/jats:italic>\u2003=60) were recruited prospectively using endoscopic and histopathological criteria. Human leucocyte antigen class I and II typing was performed using a polymerase chain reaction sequence\u2010specific primers method.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002The HLA\u2010B7 allele was present in 17% (10 of 59) of patients with Barrett's oesophagus when compared with 0% (zero of 60) of controls [<jats:italic>P<\/jats:italic>\u2003=\u20030.0006, corrected P\u2003=\u20030.0171, OR\u2003=\u200325.67]. Subgroup analysis revealed that the HLA\u2010B7 allele was confined almost exclusively to Indians with Barrett's oesophagus, 43% (nine of 21) vs. 0% (zero of 19) Indian controls (<jats:italic>P<\/jats:italic>\u2003= 0.0014, corrected P\u2003=\u20030.0406, OR\u2003=\u200329.64). No class II associations, protective human leucocyte antigens or extended haplotypes for disease susceptibility were identified.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Barrett's oesophagus in Asians, particularly Indians, is strongly positively associated with HLA\u2010B7; reinforcing a genetic component to gastro\u2010oesophageal reflux disease. A larger sample size and different ethnic populations should be genotyped to further confirm this association and identify possible additional risk factors in the human leucocyte antigen locus.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02496.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:19:18Z","timestamp":1117754358000},"page":"1377-1383","source":"Crossref","is-referenced-by-count":21,"title":["Human leucocyte antigen determinants of susceptibility to Barrett's oesophagus in Asians \u2013 a preliminary study"],"prefix":"10.1111","volume":"21","author":[{"given":"S.","family":"Rajendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ackroyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Murad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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