{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:43:08Z","timestamp":1791088988008,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the effect of a laxative alone and in combination with tegaserod in alleviating pain and improving stool frequency in adolescents with constipation predominant irritable bowel syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Forty\u2010eight postpubertal adolescents of both sexes with constipation predominant irritable bowel syndrome, as defined by Rome II criteria, were randomly allocated to Group A (<jats:italic>n<\/jats:italic>\u2003=\u200327) for treatment with a laxative (polyethylene glycol 3350 oral solution) only or Group B (<jats:italic>n<\/jats:italic>\u2003=\u200321) for combination therapy with the laxative and tegaserod. Symptoms of abdominal pain (scale 0\u201310) and frequency of bowel movements were recorded daily in the pre\u2010treatment phase and the post\u2010treatment phase after a 7\u2010day \u2018washout\u2019 period. Patients served as their own controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with the laxative alone (Group A) resulted in significant increase in frequency of bowel movements (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), but not significant improvement in pain (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). Treatment with the combination of the laxative and tegaserod (Group B) led to significant increase in the frequency of bowel movements and also significant reduction in pain (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The laxative alone improved stooling but not pain in adolescents with constipation predominant irritable bowel syndrome. Addition of tegaserod resulted in alleviation of pain as well.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02705.x","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T14:11:14Z","timestamp":1134483074000},"page":"191-196","source":"Crossref","is-referenced-by-count":69,"title":["Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"V.","family":"KHOSHOO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"ARMSTEAD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"LANDRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07027.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1136\/gut.45.2008.ii43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson WG","year":"1999","journal-title":"Gut"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70246-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-20040201-08"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01966.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-20040201-09"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01094.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310006748"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.671"},{"key":"e_1_2_6_11_2","first-page":"88","article-title":"A randomized, double\u2010blind, placebo\u2010controlled, multicenters study to assess the efficacy and safety of tegaserod in Chinese patients with constipation\u2010predominant irritable bowel syndrome","volume":"42","author":"Tegaserod Clinical Research Group","year":"2003","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_6_12_2","first-page":"21","article-title":"Efficacy and tolerability of tegaserod in constipation predominant irritable bowel syndrome","volume":"14","author":"Shah SH","year":"2004","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01709.x"},{"key":"e_1_2_6_14_2","first-page":"24","article-title":"Prevalence and risk factors of the development of irritable bowel syndrome in adolescents: a population study","volume":"73","author":"Reshetnikov OV","year":"2001","journal-title":"Ter Arkh"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00299-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50055"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)70039-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01347.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.02705.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.02705.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:47:02Z","timestamp":1697194022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.02705.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,13]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1365-2036.2006.02705.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.02705.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,13]]}}}