{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:30:05Z","timestamp":1791160205837,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Mesalazine (5\u2010aminosalicylic acid, 5\u2010ASA) containing formulations represent a cornerstone in the treatment of inflammatory bowel diseases. A novel formulation with an Eudragit L\/S mixture coating has been developed to provide selective release of 5\u2010ASA to the ileo\u2010caecal region and the colon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the release of 5\u2010ASA during the gastrointestinal transit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single oral dose of mesalazine EC 500\u2003mg gastroresistant tablets (Asamax) was administered to eight healthy male volunteers. Gastrointestinal transit and tablet disintegration were monitored by scintigraphy. 5\u2010ASA release was verified by assessing plasma pharmacokinetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial tablet disintegration was observed 5.65\u2003\u00b1\u20030.86\u2003h after dosing, corresponding to the detection of 5\u2010ASA in plasma. This occurred in the ileo\u2010caecal region in three subjects and the ascending colon in the remaining five. The relative percentage of 5\u2010ASA absorption was more pronounced in the ascending colon (41\u2003\u00b1 27.4%) than the ileo\u2010caecal region (6.6\u2003\u00b1\u20039.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This mesalazine EC gastroresistant tablets release locally active 5\u2010ASA specifically in the ileo\u2010caecal region and the ascending colon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02721.x","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T14:11:14Z","timestamp":1134483074000},"page":"137-144","source":"Crossref","is-referenced-by-count":23,"title":["5\u2010aminosalicylic acid release from a new controlled\u2010release mesalazine formulation during gastrointestinal transit in healthy volunteers"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"BRUNNER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"LACKNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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