{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:22:03Z","timestamp":1778728923821,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T00:00:00Z","timestamp":1135209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> It is unclear whether decreased serotonin transporter function contributes to sensorimotor abnormalities in irritable bowel syndrome.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To study the influence of acute serotonin transporter inhibition on colonic sensorimotor function in man.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Ten healthy subjects (five men, aged 20\u201329\u2003years) underwent a combined manometry\/barostat study of the descending colon on two occasions. Stepwise distentions by 2\u2003mmHg increments were performed until discomfort. Subsequently, placebo or citalopram 20\u2003mg were administered i.v. over 20\u2003min and distentions were repeated. Afterwards, isobaric tone measurements were performed 30\u2003min before and 90\u2003min after ingestion of a meal. High\u2010amplitude propagated contractions, colonic motility index, colonic compliance, sensitivity and colonic response to a meal after placebo or citalopram were compared by <jats:italic>t<\/jats:italic>\u2010test and two\u2010way <jats:sc>anova<\/jats:sc>.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Citalopram induced a significant increase in colonic motility index (5.6\u2003\u00b1\u20030.9 to 0.8\u2003\u00b1\u20031.9\u2003mL*min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005) and high\u2010amplitude propagated contractions (32 after citalopram vs. 2 after placebo, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), which were associated with abdominal cramping. Administration of citalopram increased colonic compliance (10.3\u2003\u00b1\u20031.5 vs. 14.5\u2003\u00b1\u20032.2\u2003mL\/mmHg, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and inhibited colonic response to a meal (volume decrease 48\u2003\u00b1\u200312 vs. 16\u2003\u00b1\u200312\u2003mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Acute serotonin transporter inhibition in man increases colonic phasic contractility and the occurrence of high\u2010amplitude propagated contractions, increases colonic compliance and suppresses the colonic tonic response to a meal. These data suggest that both release and elimination of 5\u2010hydroxytryptamine by serotonin transporter are involved in the control of colonic motility in man.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02724.x","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T09:28:33Z","timestamp":1135243713000},"page":"265-274","source":"Crossref","is-referenced-by-count":66,"title":["Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in 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