{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T18:45:39Z","timestamp":1709232339129},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate (i) the diagnostic usefulness of a delayed test in initially negative patients; and (ii) the reliability of the rapid urease test, histology or a combination of the two to diagnose <jats:italic>Helicobacter pylori<\/jats:italic> during emergency endoscopy in a large clinical practice series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Records of patients with ulcer bleeding from 1995 to 2000 were reviewed. Patients with initially negative tests were retested 4\u20138\u2003weeks after the bleeding episode. Sensitivity of urease, histology or a combination of the two to detect <jats:italic>H. pylori<\/jats:italic> at initial endoscopy and the efficacy of delayed Urea Breath Test in detecting missed infection was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 429 patients. A delayed second test detected <jats:italic>H. pylori<\/jats:italic> infection in 57 out of 72 (79%) of initially negative patients. The sensitivity for detecting <jats:italic>H. pylori<\/jats:italic> was 76%, 78% and 86% for urease, histology and their combination, respectively. The prevalence of <jats:italic>H. pylori<\/jats:italic> was 95% in duodenal and 88% in gastric ulcer. In addition, only one test was performed in 17 of the 32 patients who were considered negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Not even the combination of a negative urease and histology in the initial endoscopy is able to rule out infection in bleeding ulcer patients. A delayed test should be performed to rule out <jats:italic>Helicobacter pylori<\/jats:italic> infection completely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02726.x","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T14:11:14Z","timestamp":1134483074000},"page":"53-59","source":"Crossref","is-referenced-by-count":24,"title":["Usefulness of a delayed test for the diagnosis of <i>Helicobacter pylori<\/i> infection in bleeding peptic ulcer"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"G\u00dcELL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"ARTIGAU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"ESTEVE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"S\u00c1NCHEZ\u2010DELGADO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"JUNQUERA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"CALVET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2003.11800649"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70005-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.0160s1066.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00058-6"},{"key":"e_1_2_6_6_2","first-page":"31","article-title":"Low sensitivity of invasive tests for the detection of Helicobacter pylori infection in patients with bleeding ulcer","volume":"24","author":"Colin R","year":"2000","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-812836"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70494-4"},{"key":"e_1_2_6_9_2","first-page":"A3","article-title":"Gi bleeding does not decrease sensitivity of H\u2010pylori diagnostic testing: a prospective study in patients at the time of bleeding and one month later","volume":"128","author":"Laine L","year":"2005","journal-title":"Gastroenterology"},{"key":"e_1_2_6_10_2","first-page":"CD004062","article-title":"H. pylori eradication therapy vs. antisecretory non\u2010eradication therapy (with or without long\u2010term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer","volume":"2","author":"Gisbert JP","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02004.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529950173618"},{"key":"e_1_2_6_13_2","first-page":"59","article-title":"Peptic ulcer bleeding: is Helicobacter pylori a risk factor in an endemic area","volume":"24","author":"Sotoudehmanesh R","year":"2005","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_6_14_2","first-page":"A77","article-title":"The prevalence of Helicobacter pylori in bleeding peptic ulcer disease","volume":"45","author":"Hayat M","year":"1999","journal-title":"Gut"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018807412030"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.026"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-7-199810010-00007"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00219.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.112840"},{"key":"e_1_2_6_20_2","first-page":"395","article-title":"Diagnosis of Helicobacter pylori infection in patients with bleeding ulcer disease: rapid urease test and histology","volume":"96","author":"Castro\u2010Fern\u00e1ndez M","year":"2004","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.4.459"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026669123593"},{"key":"e_1_2_6_23_2","first-page":"A35","article-title":"Early administration of high\u2010dose intravenous omeprazole prior to endoscopy in patients with upper gastrointestinal bleeding; 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