{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:52:43Z","timestamp":1761918763219},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T00:00:00Z","timestamp":1135209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Small intestinal malignancies in humans are rare; however, patients with coeliac disease have a relatively high risk for such tumours. Intestinal UDP\u2010glucuronosyltransferases are phase II drug metabolism enzymes also involved in the detoxification of ingested toxins and carcinogens. As many toxins and carcinogens are ingested via food, the human gastrointestinal tract not only has an important role in the uptake of essential nutrients, but also acts as a first barrier against such harmful constituents of the food. Therefore, the gastrointestinal mucosa contains high levels of detoxification enzymes such as cytochromes\u2010P450, glutathione S\u2010transferases and UDP\u2010glucuronosyltransferases.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare the UDP\u2010glucuronosyltransferase detoxification capacity in small intestinal mucosa of patients with coeliac disease vs. that in normal controls.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We assessed UDP\u2010glucuronosyltransferase enzyme activities towards 4\u2010methylumbelliferone in small intestinal biopsies of patients with coeliac disease (<jats:italic>n<\/jats:italic>\u2003=\u200322) and age\u2010 and sex\u2010matched controls (<jats:italic>n<\/jats:italic>\u2003=\u200327).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Small intestinal UDP\u2010glucuronosyltransferase enzyme activity in controls was significantly higher than in patients with coeliac disease: 0.55\u2003\u00b1\u20030.27 vs. 0.35\u2003\u00b1\u20030.16\u2003nmol\/min\u2003mg protein, respectively (mean\u2003\u00b1\u2003s.d., <jats:italic>P<\/jats:italic>\u2003=\u20030.005).<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold> The low small intestinal UDP\u2010glucuronosyltransferase detoxification activity in patients with coeliac disease may result in a deficient detoxification of potential carcinogens, and thus could explain in part the relatively high small intestinal cancer risk in these patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02754.x","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T09:28:33Z","timestamp":1135243713000},"page":"243-246","source":"Crossref","is-referenced-by-count":7,"title":["Deficient UDP\u2010glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"GOERRES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M. J.","family":"ROELOFS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B. M. J.","family":"JANSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. H. M.","family":"PETERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.3.333"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90060-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.8.662"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239509083491"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.3.405"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.4.408"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.262"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01092.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.983_f.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg117"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.7.1087"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.4.397"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500171"},{"key":"e_1_2_6_15_2","first-page":"1205","article-title":"Enhancement of glutathione S\u2010transferase activity of the esophagus by phenols, lactones and benzyl isothiocyanate","volume":"42","author":"Sparnins VL","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_2","first-page":"4050","article-title":"Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH\u20101 hairless mice: possible role in cancer chemoprevention","volume":"52","author":"Rhan SG","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07379.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.02754.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:14:04Z","timestamp":1697440444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.02754.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,22]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1365-2036.2006.02754.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.02754.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,22]]}}}