{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:47:54Z","timestamp":1773269274230,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastro\u2010oesophageal reflux disease (GERD) is a common and frequently chronic condition that causes considerable costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To estimate the economic burden caused by patients with erosive and non\u2010erosive reflux disease, and Barrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Progression of Gastro\u2010oesophageal Reflux Disease study includes a total of 6215 patients. At baseline, patients were categorized as non\u2010erosive reflux disease, erosive reflux disease, or Barrett's oesophagus according to endoscopic findings alone or as confirmed by histology. Direct and indirect disease\u2010related costs were calculated based on 5273 patients with complete information in the second year of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 73% of the Progression of Gastro\u2010oesophageal Reflux Disease patients had taken GERD medication, 61% had visited a doctor, and 2% had been hospitalized because of GERD during the previous 12\u2003months. Of all employed persons, 6% reported days off work because of GERD. This health resource utilization caused direct costs of \u20ac342\u2003\u00b1\u2003864 (mean\u2003\u00b1\u2003s.d.) and indirect costs of \u20ac40\u2003\u00b1\u2003473 per patient and year. Total costs for patients with Barrett's oesophagus or erosive reflux disease were higher than those for patients with non\u2010erosive reflux disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with GERD frequently need long\u2010term medication and doctor care. The disorder is associated with a considerable health economic burden to society.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02763.x","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T10:05:03Z","timestamp":1137405903000},"page":"371-376","source":"Crossref","is-referenced-by-count":35,"title":["Cost\u2010of\u2010disease analysis in patients with gastro\u2010oesophageal reflux disease and Barrett's mucosa"],"prefix":"10.1111","volume":"23","author":[{"given":"S. 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