{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:47:59Z","timestamp":1791384479887,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Tricyclic antidepressants, which have multiple pharmacological influences, have a therapeutic effect in non\u2010cardiac chest pain, but selective serotonin reuptake inhibitors have a single pharmacological effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the acute effect of citalopram on oesophageal hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On two separate occasions, 10 healthy subjects (seven men, mean age 25\u2003years) with established oesophageal hypersensitivity, underwent oesophageal manometry with evaluation of mechanical and chemical sensitivity. Subjects received placebo or citalopram 20\u2003mg i.v. in a randomized, crossover, double\u2010blind fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Citalopram did not alter oesophageal motility. Citalopram significantly increased the threshold inducing first perception (4.6\u2003\u00b1\u20030.3 vs. 6.7\u2003\u00b1\u20030.4\u2003mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005) and discomfort (8.6\u2003\u00b1\u20030.4 vs. 9.9\u2003\u00b1\u20030.6\u2003mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) during balloon distention. It also significantly prolonged the acid perfusion time to induce perception of heartburn (6.0\u2003\u00b1\u20030.9 vs. 10.7\u2003\u00b1\u20030.6\u2003min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005) and discomfort (12.2\u2003\u00b1\u20030.8 vs. 16.7\u2003\u00b1\u20030.7\u2003mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Seven subjects experienced a retrosternal sensation during edrophonium provocation with placebo, and this was reduced to two of 10 after citalopram (<jats:italic>P<\/jats:italic>\u2003=\u20030.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute administration of citalopram significantly lowers chemical and mechanical oesophageal sensitivity in oesophageal hypersensitivity, without altering the motility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02772.x","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T10:05:03Z","timestamp":1137405903000},"page":"365-370","source":"Crossref","is-referenced-by-count":113,"title":["Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: a double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"23","author":[{"given":"D.","family":"BROEKAERT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"FISCHLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"SIFRIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"JANSSENS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"TACK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1590-8658(04)00082-9","article-title":"Visceral hypersensitivity in functional disorders of the upper gastrointestinal tract","volume":"36","author":"Sarnelli G","year":"2004","journal-title":"Dig Liver Dis"},{"key":"e_1_2_6_3_2","first-page":"247","volume-title":"Rome II: The Functional Gastrointestinal Disorders","author":"Clouse RE","year":"2000"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90685-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01299805"},{"key":"e_1_2_6_6_2","first-page":"938","article-title":"Intraesophageal balloon distention vs drug provocation in the evaluation of non\u2010cardiac chest pain","volume":"85","author":"Deschner WK","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-11-199606010-00002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02758-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.738"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92686-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405193302003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90979-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.6.807"},{"issue":"3","key":"e_1_2_6_14_2","first-page":"G460","article-title":"Differential effects of amitriptyline on perception of somatic and visceral stimulation in healthy humans","volume":"275","author":"Gorelick AB","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.108514"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_96696601.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02724.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00344.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01469.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.885"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00925.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(03)00029-3"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)80059-9"}],"container-title":["Alimentary Pharmacology &amp; 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