{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:02:42Z","timestamp":1791176562646,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx\u2010A) is a long\u2010acting inhibitor of acetylcholine\u2010mediated peristalsis, which is mainly responsible for gastric motility.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a double_blind study, 18 healthy obese subjects (body mass index &gt;30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx\u2010A133U, Btx\u2010A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10\u2003days after treatment. Body weight variations and appetite sensation were recorded after 5\u2003weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fourteen patients completed the study. The botulinum toxin A\u2010treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02773.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T16:57:53Z","timestamp":1139936273000},"page":"675-680","source":"Crossref","is-referenced-by-count":60,"title":["Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study"],"prefix":"10.1111","volume":"23","author":[{"given":"D.","family":"GUI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"MINGRONE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"VALENZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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