{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:17:09Z","timestamp":1697462229534},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Symptom diaries are potentially attractive but, because of concerns about patient compliance, they have had limited use in clinical trials. We assessed the validity and responsiveness of a symptom diary for patients with gastro\u2010oesophageal reflux disease.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We included 215 patients with gastro\u2010oesophageal reflux disease after starting treatment for 4\u2003weeks with 40\u2003mg esomeprazole once daily. Patients recorded whether they experienced night\u2010time heartburn (yes\/no), the severity of daytime heartburn on a scale from 1 (no heartburn) to 4 (severe heartburn) and their antacid use. Patients also completed a number of disease\u2010specific and preference\u2010based Health\u2010related Quality of Life questionnaires at baseline and follow\u2010up.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Consistent with <jats:italic>a priori<\/jats:italic> predictions, daytime heartburn showed moderate to strong correlations with the Quality of Life in Reflux and Dyspepsia questionnaire (0.36\u20130.67) and four scales of symptom severity (0.36\u20130.70) for baseline, follow\u2010up and change scores, but low correlations with the Standard Gamble. Responsiveness of the daytime heartburn item was excellent with a mean change from baseline to follow\u2010up of \u22121.3 (95% CI \u22121.4 to \u22121.1) and a standardized response mean of 1.33 while responsiveness of the daily antacid use item was moderate (mean change scores \u22121.8 tablets taken, 95% CI \u22122.3 to \u22121.3 and standardized response mean of 0.64).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The excellent psychometric properties of this simple gastro\u2010oesophageal reflux disease diary make it an attractive measure for future trials.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02775.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T15:45:55Z","timestamp":1137771955000},"page":"531-541","source":"Crossref","is-referenced-by-count":9,"title":["Validation of a symptom diary for patients with gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"23","author":[{"given":"M. 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