{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:47:33Z","timestamp":1789429653094,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Oesophageal adenocarcinoma is the sixth leading cause of cancer\u2010related mortality worldwide. Previously, oesophageal cancer was mainly squamous cell, presenting late with dysphagia and weight loss.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> To examine the distribution of oesophageal cancer histopathology at a large, urban hospital; to determine the tumour stage and symptoms at presentation; and to evaluate the impact of endoscopic surveillance in Barrett's oesophagus.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> From 1999 to 2004, all patients diagnosed with oesophageal cancer were evaluated retrospectively for demographics and tumour stage at presentation using endoscopic ultrasonography and computerized tomography.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 131 patients were included. 81% of tumours were adenocarcinomas; most localized to the distal oesophagus (97%). Patients presented with dysphagia (56%), pain (30%) and\/or weight loss (16%). Irrespective of histology, locally advanced lesions accounted for most cases. Thirteen patients had lesions detected in Barrett's surveillance; these were early or intermediate stage in nine patients, but late stage in four patients.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Adenocarcinoma has become the dominant histologic subtype, comprising 81% of proven malignancies. Despite a change in histopathology, most cancers are diagnosed at an advanced stage, presenting with dysphagia, pain and\/or weight loss. Endoscopic surveillance of Barrett's oesophagus allows earlier diagnosis of cancer in most, but not all, patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02782.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T16:57:53Z","timestamp":1139936273000},"page":"587-593","source":"Crossref","is-referenced-by-count":33,"title":["A survey of oesophageal cancer: pathology, stage and clinical presentation"],"prefix":"10.1111","volume":"23","author":[{"given":"B.","family":"SCHLANSKY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"JR","given":"A. 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