{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:14:16Z","timestamp":1769148856614,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Little is known about the site and nature of bleeding lesions related to low\u2010dose aspirin and other antithrombotic agents.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To describe the mucosal abnormalities in patients presenting with upper gastrointestinal bleeding while being treated with these drugs.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The endoscopic findings and clinical details were analysed in all patients presenting with haematemesis and\/or melaena at a single centre during three calendar years. Associations between endoscopic findings and risk factors, including the intake of non\u2010steroidal anti\u2010inflammatory drugs, low\u2010dose aspirin (75\u2003mg daily) and other antithrombotic drugs including warfarin, clopidogrel, and dipyridamole, were assessed by logistic regression analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In 674 upper gastrointestinal bleeders, we found that the odds ratio for the presence of erosive oesophagitis in aspirin users was 2 (95% CI, 1\u20133; <jats:italic>P<\/jats:italic>\u2003=\u20030.03) and 3 (2\u20135; <jats:italic>P<\/jats:italic>\u2003=\u20030.0003) in patients taking other antithrombotic agents. In 41 patients with oesophagitis and taking these drugs, 36 (88%) had cardiovascular disease and only 4 (10%) had peptic symptoms.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Erosive oesophagitis is common in patients with upper gastrointestinal bleeding taking low\u2010dose aspirin or antithrombotic agents, and could potentially be confused with the coexisting heart disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02784.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T15:45:55Z","timestamp":1137771955000},"page":"489-495","source":"Crossref","is-referenced-by-count":30,"title":["Upper gastrointestinal mucosal abnormalities and blood loss complicating low\u2010dose aspirin and antithrombotic therapy"],"prefix":"10.1111","volume":"23","author":[{"given":"A. S.","family":"TAHA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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