{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:16:29Z","timestamp":1776215789089,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T00:00:00Z","timestamp":1140134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Treatment of gastro\u2010oesophageal reflux disease with acid suppressive therapy is based on the principle that effective control of intragastric pH (a marker of acid control) leads to healing of erosive oesophagitis and relief of gastro\u2010oesophageal reflux disease\u2010associated symptoms.<\/jats:p><jats:p>Most patients with gastro\u2010oesophageal reflux disease can be managed successfully with current antisecretory therapy. In difficult\u2010to\u2010treat patients, oesophageal pH monitoring is a useful technique to assess pH control and to investigate the association of reflux with refractory symptoms.<\/jats:p><jats:p>Intragastric pH monitoring allows direct assessment of acid suppression achieved with an agent, and is the most useful for head\u2010to\u2010head comparisons of antisecretory therapies, evaluating variability in individual gastric pH response, assessing dose timing and food effect, and determining alternate dosing strategies; as such, it is useful in the research laboratory, and may be useful clinically to guide clinicians in dose titration and in evaluating the effect of switching agents.<\/jats:p><jats:p>This article reviews these and other uses of these tests in an effort to explore the question of how to optimally use oesophageal pH monitoring and gastric pH monitoring in patient management.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02801.x","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T09:50:17Z","timestamp":1140169817000},"page":"3-11","source":"Crossref","is-referenced-by-count":14,"title":["Review article: intragastric and oesophageal pH monitoring in patients with gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"23","author":[{"given":"P. O.","family":"KATZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41217.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01768.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.8.882"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536707"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198606001-00009"},{"key":"e_1_2_6_7_2","first-page":"358","article-title":"The symptom index: a clinically important parameter of ambulatory 24\u2010h esophageal pH monitoring","volume":"83","author":"Wiener GJ","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308595"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200401000-00007"},{"key":"e_1_2_6_10_2","first-page":"160","article-title":"The symptom sensitivity index: a valuable additional parameter in 24\u2010h esophageal pH recording","volume":"86","author":"Breumelhof R","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90815-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017940724692"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.054981"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24840"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41210.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30124.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200108000-00003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02648-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00363-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.14309\/00000434-200410001-00028","article-title":"Barrett's esophagus: How much acid suppression is enough? Predictors of response to high dose proton pump inhibitors","volume":"99","author":"Maqbool S","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)04583-5"},{"key":"e_1_2_6_22_2","first-page":"989","article-title":"Successful elimination of reflux symptoms does not insure adequate control of acid reflux in patients with Barrett's esophagus","volume":"89","author":"Katzka DA","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.211_a.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00749.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)82137-X"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08783.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01496.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03600.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05532.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01181.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00775.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00829.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00426.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01776.x"},{"key":"e_1_2_6_36_2","first-page":"1527","article-title":"Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy","volume":"91","author":"Leite LP","year":"1996","journal-title":"Am J Gastroenterol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.02801.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.02801.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:57:46Z","timestamp":1695700666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.02801.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,17]]},"references-count":35,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-2036.2006.02801.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.02801.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,17]]}}}