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Collagen replacement of vascular and enteric smooth muscle results in hypomotility, lumen dilatation, tensile rigidity and eventual loss of organ functions.<\/jats:p><jats:p>The aim of this paper is to provide an overview of systemic sclerosis\u2010related gastrointestinal dysmotility and available\/potential therapeutic options.<\/jats:p><jats:p>We evaluated published data on the pathophysiology and management of gastrointestinal dysmotility in systemic sclerosis patients using the MEDLINE database for English and non\u2010English articles from 1966 to July 2005.<\/jats:p><jats:p>Based on this systematic review, lifestyle and medical therapy approaches are preferred as they often improve and\/or ameliorate symptoms. Surgery is only recommended with serious, rare complications such as bowel perforation or ischaemia.<\/jats:p><jats:p>Alternative therapies such as acupuncture\u2010based therapies are well tolerated, with clinical improvement and may be of potential therapeutic benefit for systemic sclerosis gastrointestinal dysmotility.<\/jats:p><jats:p>Further elucidation of initiating and persistent mechanisms of systemic sclerosis\u2010related gastrointestinal dysmotility will optimize the development of a multidisciplinary and more directed treatment regimen.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02804.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T17:05:56Z","timestamp":1141059956000},"page":"691-712","source":"Crossref","is-referenced-by-count":160,"title":["Systematic review: pathophysiology and management of gastrointestinal dysmotility in systemic sclerosis (scleroderma)"],"prefix":"10.1111","volume":"23","author":[{"given":"H.","family":"SALLAM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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