{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:36:34Z","timestamp":1794562594319,"version":"4.9.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To commemorate Edkins\u2019 discovery of gastrin in 1905, we review a century of progress in the physiology and pathobiology of gastrin and acid secretion especially as it pertains to clinical aspects of gastro\u2010oesophageal reflux disease.<\/jats:p><jats:p>Although initially ignored, Edkins\u2019 observations eventually led to the enthusiastic investigation of gastrin and acid regulation in peptic ulcer disease, culminating in important therapeutic advances in the management of acid peptic disease. Following the improved understanding of gastric secretory physiology, and the development of acid suppressants with increasing efficacy, the use of surgical intervention for peptic ulcer disease was almost eliminated. Surgery became obsolete with the discovery of <jats:italic>Helicobacter pylori<\/jats:italic>.<\/jats:p><jats:p>Three other advances are also influencing modern practice: the gastrotoxicity of aspirin and non\u2010steroidal anti\u2010inflammatory drugs is now increasingly appreciated, the role of endoscopy in the diagnosis and therapy of upper gastrointestinal bleeding, and the use of intravenous acid\u2010suppressive agents.<\/jats:p><jats:p>The major issue for the future resides within the epidemic of gastro\u2010oesophageal reflux disease. How to diagnose, categorize and treat this condition and how to identify and prevent neoplasia, are the challenges of the new century.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02817.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T17:05:56Z","timestamp":1141059956000},"page":"683-690","source":"Crossref","is-referenced-by-count":21,"title":["Review article: From gastrin to gastro\u2010oesophageal reflux disease \u2013 a century of acid suppression"],"prefix":"10.1111","volume":"23","author":[{"given":"P.","family":"MALFERTHEINER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"FASS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M. M.","family":"QUIGLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"MODLIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"MALAGELADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"MOSS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"HOLTMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010L.","family":"GOH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"KATELARIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"STANGHELLINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"TALLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. N.","family":"TYTGAT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"WRIGHT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900221"},{"key":"e_1_2_7_3_2","first-page":"1753","article-title":"The chemical mechanism of gastric secretion","volume":"46","author":"Edkins JS.","year":"1906","journal-title":"J Physiol"},{"key":"e_1_2_7_4_2","volume-title":"Helicobacter Pioneers: Firsthand Accounts from the Scientists Who Discovered Helicobacters, 1892\u20131982","author":"Marshall B.","year":"2002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1902.sp000920"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509002471"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1347-5"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(04)80093-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.009"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/236385a0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00216.2003"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38356.641134.8F"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02391.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34782"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-10-200311180-00012"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2004.12.003"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.019836"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01210-1"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27997"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043984"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.014"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079707"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07699.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.10.1127"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410008141"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1658"},{"issue":"4","key":"e_1_2_7_29_2","first-page":"1","article-title":"Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs","volume":"53","author":"Dent J","year":"2004","journal-title":"Gut"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2004.01861.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40122.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080465"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02194.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079708"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04110.x"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40978.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40476.x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020580630594"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03863.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00733.x"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.022160"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.066274"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.064691"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41210.x"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01390-6"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047126"},{"key":"e_1_2_7_48_2","volume-title":"The Hunting of the Snark","author":"Carroll L.","year":"1967"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.23510"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41201.x"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70136-3"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.02817.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.02817.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:18:36Z","timestamp":1697195916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.02817.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,27]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-2036.2006.02817.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.02817.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,27]]}}}