{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:58:35Z","timestamp":1773457115792,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Barrett's surveillance is prone to sampling error.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether enhanced magnification endoscopy using acetic acid instillation improves diagnostic accuracy of specialized intestinal metaplasia\/dysplasia in Barrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the detection rate of the specialized intestinal metaplasia\/dysplasia in 64 consecutive patients with Barrett's oesophagus using acetic acid to enhance mucosal pit patterns. Histology was compared with the previous findings at recent conventional surveillance in 62 patients. We also examined the inter\u2010\/intra\u2010observer agreement in the assessment of the enhanced magnification endoscopy pit pattern findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histology revealed columnar\u2010lined oesophagus in six (9%) patients, specialized intestinal metaplasia in 49 (77%), low\u2010grade dysplasia in five (8%), high\u2010grade dysplasia in one (2%), and adenocarcinoma in three (5%). There was discordance between the histologic findings from conventional surveillance with random biopsy. Fifteen patients (24%) had a histological upgrade with enhanced magnification endoscopy. There was a high detection rate of specialized intestinal metaplasia even in short segment Barrett's oesophagus (74%), and additionally, there were two cancers, one with 2\u2010cm Barrett's oesophagus and one ultra\u2010short (1\u2003cm). The mean kappa values for inter\u2010 and intra\u2010observer agreement in assessing the pit patterns were 0.571 (0.041) and 0.709 (0.038), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Enhanced magnification endoscopy allows clear visualization of the epithelial pit patterns within Barrett's oesophagus, and targeted biopsy results in a high yield of specialized intestinal metaplasia and dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02823.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T17:05:56Z","timestamp":1141059956000},"page":"735-742","source":"Crossref","is-referenced-by-count":63,"title":["Acetic acid\u2010enhanced magnification endoscopy in the diagnosis of specialized intestinal metaplasia, dysplasia and early cancer in Barrett's oesophagus"],"prefix":"10.1111","volume":"23","author":[{"given":"P. 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