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No change in length was seen during treatment but 48% of patients developed squamous islands (25% after 1\u20133\u2003years; 100% at 12\u201313\u2003years). Squamous islands correlated with treatment duration and male sex but not with proton pump inhibitor dose or patient age. Six patients developed dysplasia and three males developed adenocarcinoma during treatment (cancer incidence 0.31%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proton\u2010pump inhibitor treatment over 1\u201313\u2003years does not shorten the Barrett's oesophagus segment but squamous islands appear in many patients. The incidence of oesophageal adenocarcinoma was low in these proton pump inhibitor\u2010treated patients compared with published series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02825.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T17:05:56Z","timestamp":1141059956000},"page":"727-733","source":"Crossref","is-referenced-by-count":87,"title":["Continuous treatment of Barrett's oesophagus patients with proton pump inhibitors up to 13\u2003years: observations on regression and cancer incidence"],"prefix":"10.1111","volume":"23","author":[{"given":"B. T.","family":"COOPER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"CHAPMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"NEUMANN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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