{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:37:46Z","timestamp":1782826666794,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Trials in functional dyspepsia report placebo response rates of 30% to 40%.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> We aimed to identify predictors of the placebo response.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients from primary, secondary and tertiary practices with functional dyspepsia defined by Rome II criteria were enrolled into one of four clinical trials; 220 patients were randomized to receive placebo. Scintigraphic assessment of gastric emptying at baseline was repeated at the end of the treatment in those with delayed emptying. After a 2\u2003week run\u2010in period, patients were followed for 8\u2003weeks on placebo. Response was assessed on a weekly basis and a responder was defined as satisfactory relief of meal\u2010related symptoms on at least 50% of weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean age was 44\u2003years (range 18\u201382) and 74% were female; 76 (35%) were placebo responders. The predominant symptom was an unstable measure over the trial. Independent predictors of a lower placebo response were lower body mass index and a more consistent predominant symptom pattern (both <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). No association was seen with age, gender, centre type, baseline symptom score, baseline or change in gastric emptying, or baseline quality of life.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In functional dyspepsia, a consistent predominant symptom pattern and lower body mass index may be associated with a lower placebo response rate.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02845.x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T10:06:58Z","timestamp":1142590018000},"page":"923-936","source":"Crossref","is-referenced-by-count":80,"title":["Predictors of the placebo response in functional dyspepsia"],"prefix":"10.1111","volume":"23","author":[{"given":"N. J.","family":"TALLEY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"LOCKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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