{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:08:37Z","timestamp":1767913717687,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> It is controversial whether serum ghrelin concentration is altered in coeliac disease and whether this alteration is related to nutritional impairment or to inflammatory changes of duodenal mucosa.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate clinical and histopathological variables affecting circulating ghrelin in coeliac patients by comparison with dyspeptic patients and with healthy controls.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We measured serum ghrelin and obtained gastric and duodenal biopsies in 44 coeliac patients before and after 1\u2010year gluten\u2010free diet, in 39 dyspeptic patients and 53 healthy controls.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum ghrelin concentration was significantly higher in coeliac (531\u2003\u00b1 29 pg\/mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and in dyspeptic patients (526\u2003\u00b1\u200314\u2003pg\/mL, <jats:italic>P<\/jats:italic>\u2003&lt; 0.01) than in healthy controls (451\u2003\u00b1\u20038\u2003pg\/mL), and body mass index was significantly lower in coeliac (20\u2003\u00b1\u20031) and in dyspeptic patients (20\u2003\u00b1\u20031) than in healthy controls (22\u2003\u00b1\u20031, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). In coeliac patients serum ghrelin concentration was not related to the severity of duodenal lesions. Serum ghrelin reverted to normal (399\u2003\u00b1\u200330\u2003pg\/mL) and body mass index increased significantly (0.6\u2003\u00b1\u20030.1\u2003kg\/m<jats:sup>2<\/jats:sup> increase, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) during gluten\u2010free diet despite persistent duodenal lymphocytic infiltration.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Ghrelin concentration is increased and body mass index is decreased in coeliac and in dyspeptic patients irrespective of presence and severity of duodenal inflammation. Nutritional impairment is a key factor in elevating plasma ghrelin levels in coeliac disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02852.x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T10:06:58Z","timestamp":1142590018000},"page":"907-913","source":"Crossref","is-referenced-by-count":41,"title":["Circulating ghrelin level is increased in coeliac disease as in functional dyspepsia and reverts to normal during gluten\u2010free diet"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"LANZINI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"MAGNI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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