{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:05:08Z","timestamp":1793217908734,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare the therapeutic effectiveness and tolerability of low daily doses of polyethylene glycol 4000 vs. lactulose in the treatment of neurogenic constipation in children with myelomeningocele.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sixty\u2010seven children with chronic neurogenic constipation were randomized allocated to receive either polyethylene glycol 4000 (0.50\u2003g\/kg) or lactulose (1.5\u2003g\/kg) for 6\u2003months. Patients or their parents reported frequency and modality of evacuation and side effects on a diary card. Primary outcome was bowel frequency \u22653\/week, and the second one was side effects at the end of treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete remission of constipation was reported by a significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) higher number of patients treated with polyethylene glycol compared with lactulose. At the end of the study, 46% patients of polyethylene glycol group and 22% of the lactulose group were asymptomatic. Compared with lactulose, patients treated with polyethylene glycol reported higher bowel frequency (5.1 vs. 2.9 bowel movements\/week, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and reduction of encopresis. Neither lactulose nor polyethylene glycol caused clinically\u2010significant serious side effects and palatability was similar.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Polyethylene glycol 4000 compared with lactulose provided a higher success rate, without significant side effects, for the treatment of constipation in myelomeningocele children.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02872.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T09:49:25Z","timestamp":1143712165000},"page":"1259-1265","source":"Crossref","is-referenced-by-count":45,"title":["Polyethylene glycol 4000 vs. lactulose for the treatment of neurogenic constipation in myelomeningocele children: a randomized\u2010controlled clinical 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