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Despite their clinical efficacy, when given once daily, currently available proton pump inhibitors may not adequately control intragastric acidity during the night in a significant proportion of both healthy subjects and GERD patients, in whom symptom relief remains suboptimal.<\/jats:p><jats:p>Although some novel proton pump inhibitors have been synthesized, only few reached clinical testing. Amongst them, tenatoprazole represents a true advance displaying a long half\u2010life (five to seven times longer than that of currently available drugs) and extended acid suppression covering both day and night. All the available clinical studies suggest both pharmacokinetic and pharmacodynamic advantages of tenatoprazole over esomeprazole. As this last compound provides \u2013 amongst the members of the class \u2013 the most effective control of intragastric pH whatever the parameter considered, it is conceivable that tenatoprazole could similarly be better than the other existing proton pump inhibitors.<\/jats:p><jats:p>Tenatoprazole appears to be a promising proton pump inhibitor for the treatment of acid\u2010related diseases, where it has the potential to address unmet clinical needs.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.02945.x","type":"journal-article","created":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T09:52:16Z","timestamp":1147686736000},"page":"23-34","source":"Crossref","is-referenced-by-count":33,"title":["Review article: the opportunities and benefits of extended acid suppression"],"prefix":"10.1111","volume":"23","author":[{"given":"C.","family":"SCARPIGNATO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"PELOSINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.04.007"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20440"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.06.014"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02715.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200405000-00001"},{"key":"e_1_2_7_7_2","first-page":"509","article-title":"The pattern of nocturnal and diurnal esophageal acid exposure in the pathogenesis of erosive mucosal damage","volume":"89","author":"Orr WC","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200501000-00021"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2005.00518.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0184"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1997.tb03675.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70004-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070393"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01455.x"},{"issue":"2","key":"e_1_2_7_15_2","first-page":"A523","article-title":"A comparison of the new lansoprazole orally disintegrating tablets (LODT) tablets with esomeprazole in patients with non erosive reflux disease","volume":"128","author":"Baldi F","year":"2005","journal-title":"Gastroenterology"},{"key":"e_1_2_7_16_2","first-page":"349","article-title":"Omeprazole\/Antacid\u2010powder suspension\u2010Santarus: omeprazole\/sodium bicarbonate powder\u2010Santarus, SAN 05","volume":"5","author":"Anonymous","year":"2004","journal-title":"Drugs R&D"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02709.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02513.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.14.2501"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.05.005"},{"key":"e_1_2_7_21_2","unstructured":"ClinicalTrials.gov. 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