{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:45:19Z","timestamp":1792604719586,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T00:00:00Z","timestamp":1150416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of <jats:italic>Helicobacter pylori<\/jats:italic> eradication on the development of gastro\u2010oesophageal reflux disease is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the incidence of symptoms of reflux disease and of erosive oesophagitis, and the relationship to changes in histological gastritis, in patients with non\u2010ulcer dyspepsia over 12\u2003months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and ninety\u2010three patients in two similar randomized placebo controlled trials of <jats:italic>H. pylori<\/jats:italic> eradication in non\u2010ulcer dyspepsia were studied. Symptoms were assessed using the validated Gastrointestinal Symptom Rating Scale during a 1\u2010week run\u2010in period, at 6\u2003months and 12\u2003months. Endoscopy was performed at baseline to exclude patients with pathology and at 3\u2003months and 12\u2003months to determine if oesophagitis was present. Gastric biopsies were scored using the modified Sydney Classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients without predominant heartburn, oesophagitis or ulcers at endoscopy were randomized to active (<jats:italic>n<\/jats:italic>\u2003=\u2003297, omeprazole, amoxicillin and clarithromycin) treatment or to placebo\/omeprazole (<jats:italic>n<\/jats:italic>\u2003=\u2003306) for 1\u2003week. The eradication rate was 82% in the active treatment group. Antrum\u2010predominant gastritis (55%) was more frequently found than corpus\u2010predominant gastritis (6%). In patients with antrum\u2010predominant gastritis, heartburn and regurgitation scores improved significantly 12\u2003months after eradication. Erosive oesophagitis developed in 15\/232 patients in the eradication group (7%) compared with 2\/227 (2%) in the control group, but there was no significant difference when adjusted for oesophagitis present at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antrum\u2010predominant gastritis is the most common pattern of gastritis seen in non\u2010ulcer dyspepsia in Western populations. Heartburn and regurgitation improve after eradication therapy or placebo in patients with non\u2010ulcer dyspepsia; the development of oesophagitis is uncommon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02964.x","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T10:22:12Z","timestamp":1150453332000},"page":"55-63","source":"Crossref","is-referenced-by-count":34,"title":["Patterns of gastritis and the effect of eradicating <i>Helicobacter pylori<\/i> on gastro\u2010oesophageal reflux disease in Western patients with non\u2010ulcer dyspepsia"],"prefix":"10.1111","volume":"24","author":[{"given":"N.","family":"VAKIL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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