{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:37:46Z","timestamp":1754397466752},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T00:00:00Z","timestamp":1151280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Up to 40% of patients with non\u2010erosive reflux disease (NERD) fail to respond to proton pump inhibitor therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine useful prognostic factors for response to and suppression in NERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pooled analysis from three multicentre, double\u2010blind trials of patients with a normal endoscopy and heartburn for 4\u2003days or more during the 7\u2003days prior to the start of each treatment. Patients received omeprazole 20\u2003mg, esomeprazole 20\u2003mg or esomeprazole 40\u2003mg\/day for 4\u2003weeks. Complete resolution of heartburn was defined as no heartburn during the last week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2458 patients included, complete heartburn resolution was achieved in 63% at the end of 4\u2003weeks treatment. Response on days 5\u20137 provided an 85% probability of complete resolution of heartburn at 4\u2003weeks; the probability of complete heartburn resolution at 4\u2003weeks in those with moderate to severe symptoms on days 5\u20137 was 22%. Sensitivity and specificity of no heartburn on days 5\u20137 was 55% and 83% respectively. Patient demographics, duration of symptoms, medications used, other symptoms and body mass index were not predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Assessment of heartburn resolution during the first week of therapy was the best predictor of treatment success at 4\u2003weeks in non\u2010erosive reflux disease, but was suboptimal as a test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.02983.x","type":"journal-article","created":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T15:49:50Z","timestamp":1151336990000},"page":"371-376","source":"Crossref","is-referenced-by-count":39,"title":["Predictors of treatment response in patients with non\u2010erosive reflux disease"],"prefix":"10.1111","volume":"24","author":[{"given":"N. 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