{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:30:28Z","timestamp":1790850628930,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> After variceal bleeding, cirrhotic patients should receive secondary prophylaxis.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare nadolol plus 5\u2010isosorbide mononitrate (5\u2010ISMN) with endoscopic band ligation. The end points were rebleeding, treatment failure and death.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> One hundred and nine cirrhotic patients with a recent variceal bleeding were randomized: nadolol plus 5\u2010ISMN in 57 patients and endoscopic band ligation in 52 patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean follow\u2010up was 17 and 19\u2003months in nadolol plus 5\u2010ISMN and endoscopic band ligation groups, respectively. No differences were observed between groups in upper rebleeding (47% vs. 46%), variceal rebleeding (40% vs. 36%), failure (32% vs. 22%), major complications (7% vs. 13.5%) and death (19% vs. 20%), respectively. The actuarial probability of remaining free of rebleeding, failure and deaths were similar in both groups. Time to rebleeding shows that endoscopic band ligation patients had an early rebleed, with a median of 0.5\u2003month (95% CI: 0.0\u20134.2) compared with patients from nadolol plus 5\u2010ISMN, 7.6\u2003months (95% CI: 2.9\u201312.3, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.013). Multivariate analysis indicated that outcome\u2010specific predictive factor(s) for rebleeding was Child A vs. B\u2003+\u2003C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01); for failure was Child A vs. B\u2003+\u2003C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02); and for death ascites (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and rebleeding (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> This trial suggests no superiority of endoscopic band ligation over nadolol plus 5\u2010ISMN mononitrate for the prevention of rebleeding in cirrhotic patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03007.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T13:52:00Z","timestamp":1152539520000},"page":"601-611","source":"Crossref","is-referenced-by-count":52,"title":["Comparative study between nadolol and 5\u2010isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"G.","family":"ROMERO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"KRAVETZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"ARGONZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"VULCANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SUAREZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"FASSIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"DOMINGUEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BOSCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"MU\u00d1OZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"SALGADO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"TERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320309"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90144-X"},{"key":"e_1_2_9_4_2","first-page":"72","volume-title":"Portal Hypertension. 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