{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:43:02Z","timestamp":1776422582794,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T00:00:00Z","timestamp":1153785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Ingestion of capsaicin reduces symptoms in functional dyspepsia but induces upper abdominal symptoms initially.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the effects of one week of oral dosing with capsaicin on mechanonociception and chemonociception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy subjects ingested capsules containing 0.5\u2003mg capsaicin t.d.s (<jats:italic>n<\/jats:italic>\u2003=\u20038) or placebo (<jats:italic>n<\/jats:italic>\u2003=\u20035) for 7\u2003days. Before (day 0) and after (day 8) capsule ingestion the jejunum was distended with a balloon and perfused with a capsaicin solution. A graded questionnaire evaluated distension\u2010 and capsaicin\u2010induced sensation, aggregate perception scores were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infusion of capsaicin induced sensations similar to distension. In subjects receiving capsaicin capsules, mean\u2003\u00b1\u2003S.E.M. perception scores at 24\u2003mL distension volumes were 4.7\u2003\u00b1\u20031.2 (day 0) and 3.2\u2003\u00b1\u20031.3 (day 8, N.S.). Distension with 40\u2003mL induced perception scores of 10.3\u2003\u00b1\u20031.0 vs. 8.2\u2003\u00b1\u20031.0 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). During capsaicin perfusion, first sensation was reported after 13.2\u2003\u00b1\u20031.9\u2003min (day 0) and 8.1\u2003\u00b1\u20030.8\u2003min (day 8, N.S.), discomfort thresholds after 44.1\u2003\u00b1\u20036.0 and 31.2\u2003\u00b1\u20035.7\u2003min (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). In the placebo group, mechano\u2010 and chemonociception remained unaltered on days 0 and 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One week of ingestion of capsaicin sensitized chemonociceptors, while sensitivity of mechanonociceptors for distension decreased. Painful sensations during the first week of treatment with capsaicin can be attributed to a sensitizing effect of capsaicin on vanilloid receptors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03022.x","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T13:13:45Z","timestamp":1153833225000},"page":"679-686","source":"Crossref","is-referenced-by-count":34,"title":["Effect of repeated capsaicin ingestion on intestinal chemosensation and mechanosensation"],"prefix":"10.1111","volume":"24","author":[{"given":"J.","family":"HAMMER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"143","article-title":"Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons","volume":"43","author":"Holzer P","year":"1991","journal-title":"Pharmacol 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