{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:19:30Z","timestamp":1760188770634},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously shown reversal of E\u2010cadherin methylation in gastric mucosa from patients with dyspepsia at week 6 after <jats:italic>Helicobacter pylori<\/jats:italic>\u2010eradication therapy. But the long\u2010term methylation status of these patients was unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the methylation status at E\u2010cadherin at year 3 after <jats:italic>H. pylori<\/jats:italic>\u2010eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>35 patients (25 with and 10 without <jats:italic>H. pylori<\/jats:italic> eradicated) enrolled in our previous study were recruited into the present study (year 3 analysis). Methylation at E\u2010cadherin was evaluated by methylation\u2010specific polymerase chain reaction method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in age and sex distribution in the two groups. Methylation at E\u2010cadherin in patients with <jats:italic>H. pylori<\/jats:italic> eradicated at weeks 0, 6 and year 3 were 52%, 20% and 20%, respectively. Concordant methylation status at week 6 and year 3 was 92%. Methylation at E\u2010cadherin in patients without <jats:italic>H. pylori<\/jats:italic> at weeks 0, 6 and year 3 were 50%, 60% and 60%, respectively. Concordant methylation status between week 6 and year 3 was 90%. Stability of E\u2010cadherin methylation status was associated with histological changes. No association between E\u2010cadherin methylation status and age was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The methylation pattern is stable for a long period, thus suggesting the effect of environment on methylation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03032.x","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T09:21:33Z","timestamp":1155720093000},"page":"831-836","source":"Crossref","is-referenced-by-count":10,"title":["Stability of E\u2010cadherin methylation status in gastric mucosa associated with histology changes"],"prefix":"10.1111","volume":"24","author":[{"given":"A. O. O.","family":"CHAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"HUI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"CHO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"YUEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"LAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"RASHID","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. C.\u2010Y.","family":"WONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/32918"},{"key":"e_1_2_6_3_2","first-page":"4086","article-title":"Identification of germ\u2010line E\u2010cadherin mutations in gastric cancer families of European origin","volume":"58","author":"Gayther SA","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","first-page":"3845","article-title":"E\u2010cadherin gene mutations provide clues to diffuse type gastric carcinomas","volume":"54","author":"Becker KF","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/79120"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60806-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.7.569"},{"key":"e_1_2_6_8_2","first-page":"2847","article-title":"CpG island methylation in premalignant stages of gastric carcinoma","volume":"6","author":"Kang GH","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02998.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.502"},{"key":"e_1_2_6_11_2","volume-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Schistosomes, Liver Flukes, Helicobacter pylori. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","year":"1994"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2096"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.077776"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64195-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02283.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00947.x"},{"key":"e_1_2_6_17_2","first-page":"1547","article-title":"Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections","volume":"150","author":"Moskaluk CA","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9821"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.2033"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2727"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03032.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03032.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:52:00Z","timestamp":1697179920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03032.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,16]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03032.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03032.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,16]]}}}