{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:26:53Z","timestamp":1791178013899,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p> <jats:italic>Escherichia coli<\/jats:italic> O157:H7 is a foodborne pathogen causing haemorrhagic colitis, which is sometimes complicated by haemolytic uraemic syndrome or thrombotic thrombocytopenic purpura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the available evidence regarding the question of whether antibiotics are effective or harmful for the treatment of patients infected with <jats:italic>E. coli<\/jats:italic> O157:H7 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched in the PubMed for relevant laboratory and clinical studies published between 1982 and 2005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> <jats:italic>In vitro<\/jats:italic> studies have shown that most <jats:italic>E. coli<\/jats:italic> O157:H7 isolates are susceptible to various antibiotics, although certain antibiotics, especially at sublethal concentrations, have been found to increase the release of Shiga\u2010like toxins, which have been associated with the development of haemolytic uraemic syndrome\/thrombotic thrombocytopenic purpura in humans. No clinical studies have indicated that antibiotics are effective in reducing the duration of <jats:italic>E. coli<\/jats:italic> O157:H7 infection or the duration of diarrhoea or bloody diarrhoea specifically, while a few studies have supported that some antibiotics, especially quinolones and fosfomycin, may prevent the development of haemolytic uraemic syndrome or thrombotic thrombocytopenic purpura. On the other hand, there are some clinical studies that associate antibiotics with a higher risk for haemolytic uraemic syndrome and\/or longer duration of diarrhoea, even with high mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More randomized controlled trials are necessary in order to elucidate whether antibiotics are effective in reducing the morbidity and mortality of <jats:italic>E. coli<\/jats:italic> O157:H7 infection, rather than having a detrimental effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03036.x","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T09:21:33Z","timestamp":1155720093000},"page":"731-742","source":"Crossref","is-referenced-by-count":95,"title":["Systematic review: are antibiotics detrimental or beneficial for the treatment of patients with <i>Escherichia coli<\/i> O157:H7 infection?"],"prefix":"10.1111","volume":"24","author":[{"given":"G. Z.","family":"PANOS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. I.","family":"BETSI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"FALAGAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303243081203"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71144-2"},{"key":"e_1_2_9_4_2","first-page":"853","article-title":"Enterohemorrhagic Escherichia coli O157:H7 \u2013 an emerging pathogen","volume":"56","author":"Koutkia P","year":"1997","journal-title":"American Family Physician"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70208-9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.8.996"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4496-4498.1998"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800066462"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6387911"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(88)90036-8"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)80091-3"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb13756.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-9-705"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-9-199511010-00009"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/322598"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330608"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712103172410"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0605.000503"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-6-738"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.2.338"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36467-7"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.2.553"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.6.994"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806233182515"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.7.722"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2004.05.001"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.22.4.614-619.1985"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1986.tb01516.x"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01704889"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00126-6"},{"key":"e_1_2_9_31_2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1139\/w99-069","article-title":"Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7","volume":"45","author":"Yoh M","year":"1999","journal-title":"Can J Microbiol"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050181"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1997.tb01072.x"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268897007541"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/315239"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.71.130"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050348"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01376.x"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.73.1054"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80405-5"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.6.1606"},{"key":"e_1_2_9_42_2","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/jcm.25.8.1486-1489.1987","article-title":"Unusual verotoxin\u2010producing Escherichia coli associated with hemorrhagic colitis","volume":"25","author":"Bopp CA","year":"1987","journal-title":"J Clin Microbiol"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-10-812"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-7-199704010-00002"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.576-581.2002"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2005.03.006"},{"key":"e_1_2_9_47_2","first-page":"686","article-title":"Sporadic cases of hemolytic uremic syndrome and hemorrhagic colitis with serum IgM antibodies to lipopolysaccharides of enterohemorrhagic Escherichia coli O157","volume":"55","author":"Shiomi M","year":"1997","journal-title":"Nippon Rinsho Japanese Journal of Clinical Medicine"},{"key":"e_1_2_9_48_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1128\/AAC.42.2.431","article-title":"Antibiotic susceptibility of enterohemorrhagic Escherichia coli O157:H7 isolated from an outbreak in Japan in 1996","volume":"42","author":"Tsuboi I","year":"1998","journal-title":"Antimicrobiol Agents Chemother"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81600-2"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430030043031"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1086\/515258"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006293422601"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712103172403"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010253231703"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81609-9"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.72.266"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.1999.4121038.x"},{"key":"e_1_2_9_58_2","first-page":"357","article-title":"Effect of early fosfomycin treatment on prevention of hemolytic uremic syndrome accompanying Escherichia coli O157:H7 infection","volume":"52","author":"Ikeda K","year":"1999","journal-title":"Clin Nephrol"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81209-0"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.1.e12"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040833"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-5-624"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.4.631"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.259.24.3567"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03036.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03036.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:52:10Z","timestamp":1697179930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03036.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,16]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03036.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03036.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,16]]}}}