{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:09:46Z","timestamp":1793196586864,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>No randomized controlled trial has compared all the licensed standard dose proton pump inhibitors in the healing of reflux oesophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the effectiveness of esomeprazole with licensed standard dose proton pump inhibitors for healing of reflux oesophagitis (i.e. lansoprazole 30\u2003mg, omeprazole 20\u2003mg, pantoprazole 40\u2003mg and rabeprazole 20\u2003mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review of CENTRAL, BIOSIS, EMBASE and MEDLINE for randomized controlled trials in patients with reflux oesophagitis. Searching was completed in February 2005. Data on endoscopic healing rates at 4 and 8\u2003weeks were extracted and re\u2010analysed if not analysed by intention\u2010to\u2010treat. Meta\u2010analysis was conducted using a fixed effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 133 papers identified in the literature search, six were of sufficient quality to be included in the analysis. No studies were identified comparing rabeprazole with esomeprazole. A meta\u2010analysis of healing rates of esomeprazole 40\u2003mg compared with standard dose proton pump inhibitors gave the following results: at 4\u2003weeks [relative risk (RR) 0.92; 95% CI: 0.90, 0.94; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001], and 8\u2003weeks (RR 0.95; 95% CI: 0.94, 0.97; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001). Publication bias did not have a significant impact on the results. The results were robust to changes in the inclusion\/exclusion criteria and using a random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Esomeprazole consistently demonstrates higher healing rates when compared with standard dose proton pump inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03074.x","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T09:21:33Z","timestamp":1155720093000},"page":"743-750","source":"Crossref","is-referenced-by-count":74,"title":["Systematic review: proton pump inhibitors (PPIs) for the healing of reflux oesophagitis \u2013 a comparison of esomeprazole with other PPIs"],"prefix":"10.1111","volume":"24","author":[{"given":"S. J.","family":"EDWARDS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"LIND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"LUNDELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01128.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01562.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01756.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312013092204"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290060030"},{"key":"e_1_2_7_8_2","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_7_9_2","volume-title":"Meta\u2010analysis, Decision Analysis, and Cost\u2010effectiveness Analysis: Methods for Quantitative Synthesis in Medicine","author":"Petitti DB","year":"2000"},{"key":"e_1_2_7_10_2","volume-title":"Review Manager (RevMan) [Computer program]","year":"2000"},{"key":"e_1_2_7_11_2","volume-title":"StatsDirect Statistical Software","author":"StatsDirect Ltd","year":"2002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05532.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200222020-00004"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02339.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00856.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03600.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200404000-00007"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02368.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9062-4"},{"key":"e_1_2_7_22_2","volume-title":"National Institute for Clinical Excellence (NICE) Clinical Guideline: Dyspepsia \u2013 Management of Dyspepsia in Adults in Primary Care (August 2004)","author":"Newcastle Guideline Development and Research Unit"},{"key":"e_1_2_7_23_2","first-page":"29","article-title":"Is there such an entity as mild oesophagitis?","volume":"4","author":"Green JRB","year":"1993","journal-title":"Eur J Clin Res"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007857.15694.15"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.12.001"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03074.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03074.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:52:23Z","timestamp":1697179943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03074.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,16]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03074.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03074.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,16]]}}}