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Numerous current and emerging therapies aimed at normalizing brain\u2013gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was completed for preclinical and clinical studies related to central modulation of gastrointestinal functions and published in English between 1980 and 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Existing data, while sparse, support the use of different classes of antidepressant drugs, including tricyclics, and selective and non\u2010selective serotonin reuptake inhibitors in irritable bowel syndrome. Serotonin receptor agonists and antagonists with peripheral and possibly central effects are effective in treating specific subtypes of irritable bowel syndrome. Based largely on theoretical and preclinical evidence, several novel compounds that selectively target receptors at multiple levels within the brain\u2013gut axis such as neurokinin, somatostatin and corticotropin\u2010releasing factor receptor antagonists are promising.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review discusses the rationale for modulation of the brain\u2013gut axis in the treatment of functional gastrointestinal disorders and highlights the most promising current and future therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03078.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T09:39:32Z","timestamp":1157017172000},"page":"919-933","source":"Crossref","is-referenced-by-count":102,"title":["Review article: modulation of the brain\u2013gut axis as a therapeutic approach in gastrointestinal disease"],"prefix":"10.1111","volume":"24","author":[{"given":"E. 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