{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:31:27Z","timestamp":1761561087853},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Tegaserod is a partial 5\u2010hydroxytryptamine 4 receptor agonist with prokinetic effects on the gastrointestinal tract, its effects on oesophageal function are unknown.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> A randomized, placebo controlled, double\u2010blind trial assessed the effect of tegaserod on the oesophagus in healthy, asymptomatic subjects.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> A 7\u2010day course of tegaserod 6\u2003mg b.d. vs. placebo was prescribed (<jats:italic>n<\/jats:italic>\u2003= 17\/21 completed both phases of study). High\u2010resolution manometry and pH measurements were performed before and after a test meal. Bolus transport of liquids and solids was studied by high\u2010resolution manometry and videofluoroscopy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Tegaserod had no effect on lower oesophageal sphincter pressure compared with placebo, peristaltic velocity increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and distal contractile pressure decreased slightly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Transient lower oesophageal sphincter relaxations and reflux were infrequent regardless of treatment. During the studies of bolus transport, high\u2010resolution manometry revealed that tegaserod promoted mid\u2010oesophageal contractility (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02) and shortened the \u2018proximal transition zone\u2019 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), the level where bolus escape occurred most frequently. These effects had no effect on liquid bolus transport; however a non\u2010significant trend to improved solid bolus transport was observed (66% vs. 31%;<jats:italic>P<\/jats:italic>\u2003=\u20030.07).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Tegaserod did not alter lower oesophageal sphincter pressure, but had significant effects on peristaltic function. High\u2010resolution manometry promoted mid\u2010oesophageal contractility during bolus transport. This effect was associated with a non\u2010significant trend to improved solid bolus transit.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03090.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T08:25:28Z","timestamp":1158049528000},"page":"1017-1027","source":"Crossref","is-referenced-by-count":60,"title":["The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high\u2010resolution manometry and videofluoroscopy"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"FOX","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"MENNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"STUTZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"FRIED","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"SCHWIZER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00925.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01094.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70251-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01103.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90622-6"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447010-00008"},{"key":"e_1_2_7_8_2","first-page":"177","article-title":"Prepulsid withdrawn from UK & US markets","volume":"19","author":"Griffin JP","year":"2000","journal-title":"Adverse Drug React Toxicol Rev"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05986.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00854.x"},{"key":"e_1_2_7_11_2","first-page":"619","article-title":"Segmental high amplitude peristaltic contractions in the distal esophagus","volume":"84","author":"Freidin N","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_12_2","first-page":"1381","article-title":"\u2018\u2018Segmental aperistalsis\u2019\u2019 of the esophagus: a cause of chest pain and dysphagia","volume":"83","author":"Traube M","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90010-I"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02493487"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2005"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00539.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30035.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074690"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01126.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417902"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00280.2005"},{"key":"e_1_2_7_22_2","first-page":"G128","article-title":"Criteria for objective definition of transient lower esophageal sphincter relaxation","volume":"268","author":"Holloway RH","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1991.261.4.G677"},{"key":"e_1_2_7_24_2","first-page":"434","article-title":"Bravo vs. catheter pH monitoring","volume":"55","author":"Fox M","year":"2006","journal-title":"Gut"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01045.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540041"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00387.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00279.2001"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.94266000.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70203-3"},{"key":"e_1_2_7_31_2","first-page":"A52","article-title":"Effects of tegaserod on oesophageal bolus transport","author":"Tutuian R","year":"2005","journal-title":"Gut"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(08)81090-6"},{"key":"e_1_2_7_33_2","doi-asserted-by":"crossref","first-page":"S","DOI":"10.14309\/00000434-200509001-00046","article-title":"An exploratory open label trial of tegaserod in non\u2010erosive GERD patients with incomplete response to PPIs","volume":"100","author":"Rodriguez\u2010Stanley S","year":"2005","journal-title":"Am J Gastroenterol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03090.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03090.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T07:10:31Z","timestamp":1697181031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03090.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,12]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03090.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03090.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,12]]}}}