{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:06:30Z","timestamp":1761764790143},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Sildenafil is an inhibitor of type 5 phosphodiesterase. It relaxes or inhibits contraction of smooth muscle by increasing cellular concentrations of cyclic guanosine monophosphate. Multichannel intraluminal impedance manometry\/pH allow the precise evaluation of oesophageal bolus transit and acid\/non\u2010acid reflux.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate the effect of sildenafil on segmental oesophageal motor function and gastro\u2010oesophageal reflux.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Eight healthy volunteers underwent multichannel intraluminal impedance manometry baseline, and 15, 30 and 45\u2003min before and after a 50\u2010mg dose of sildenafil successively. The subjects underwent 2\u2010h multichannel intraluminal impedance\/pH studies on two separate days after either water or sildenafil ingestion.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Sildenafil decreased the resting lower oesophageal sphincter pressure and prolonged the duration of lower oesophageal sphincter relaxation for the 45\u2003min following its ingestion. At 15\u2003min, distal onset velocity, total bolus transit time, bolus presence time and segmental transit time were delayed in the mid to distal oesophagus. At 30\u2003min, distal onset velocity was restored but bolus presence time and bolus presence time were still delayed in distal smooth muscle segment. At 45\u2003min, total bolus transit time and distal onset velocity were restored but bolus presence time and segmental transit time were delayed more in the transition zone. Sildenafil did not alter the reflux.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Sildenafil alters lower oesophageal sphincter function and oesophageal bolus transit, but not induce gastro\u2010oesophageal reflux.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03091.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T08:25:28Z","timestamp":1158049528000},"page":"1029-1036","source":"Crossref","is-referenced-by-count":22,"title":["The effect of sildenafil on segmental oesophageal motility and gastro\u2010oesophageal reflux"],"prefix":"10.1111","volume":"24","author":[{"given":"H. S.","family":"KIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"CONKLIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213288"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.3.G567"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0024-3205(98)00158-1","article-title":"Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum muscle cells","volume":"62","author":"Moreland RB","year":"1998","journal-title":"Life Sci"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05322.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012383424783"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.758"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1350-1925.2003.00450.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200309000-00004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24840"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01394.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00271.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1991.tb00061.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805143382001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.451"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08285-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00279.2001"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90692-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.784"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03091.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03091.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T07:10:33Z","timestamp":1697181033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03091.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,12]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03091.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03091.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,12]]}}}