{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:02:04Z","timestamp":1765609324142},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To investigate the influence of delaying gastric emptying rate in healthy volunteers on the occurrence of meal\u2010related symptoms.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fourteen healthy subjects (six men, mean age 23\u2003\u00b1\u20031) underwent gastric emptying studies twice using the <jats:sup>14<\/jats:sup>C octanoic acid and <jats:sup>13<\/jats:sup>C glycin breath test after pre\u2010treatment with saline or sumatriptan 6\u2003mg s.c. Breath samples were taken before meal and at 15\u2010min intervals for a period of 360\u2003min postprandially. At each breath sampling, the subject was asked to grade the intensity (0\u20136) of four dyspeptic symptoms.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Sumatriptan pre\u2010treatment significantly delayed solid but not liquid gastric emptying (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> respectively 159\u2003\u00b1\u200311 vs. 112\u2003\u00b1\u20039\u2003min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005 and 134\u2003\u00b1\u200311 vs. 116\u2003\u00b1\u200312\u2003min, N.S.). Sumatriptan significantly decreased the mean cumulative symptom score (21.3\u2003\u00b1\u20035.5 vs. 8.0\u2003\u00b1\u20032.6, <jats:italic>P<\/jats:italic>\u2003=\u20030.01), as well as scores for each individual symptom.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A moderate delay in gastric emptying in health is not associated with an increase of meal\u2010related symptoms. This observation argues against a causal role for delayed gastric emptying in the pathogenesis of dyspeptic symptoms.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03095.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T08:25:28Z","timestamp":1158049528000},"page":"1045-1050","source":"Crossref","is-referenced-by-count":15,"title":["Influence of delaying gastric emptying on meal\u2010related symptoms in healthy 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