{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:22:25Z","timestamp":1790806945404,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> In consensus guidelines, proton pump inhibitors (PPIs) are recommended for the treatment of functional dyspepsia. It is unclear whether PPIs change gastric volume or emptying.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To assess the effect of a PPI, rabeprazole, on gastric volume and emptying and postprandial symptoms.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a double\u2010blind, parallel\u2010group placebo\u2010controlled trial, 13 healthy participants were randomized to rabeprazole, 20\u2003mg b.d., or placebo. On day 3, fasting gastric volume was measured using intravenous <jats:sup>99m<\/jats:sup>Tc\u2010pertechnate and single photon emission computed tomography (SPECT). After the last dose of study medication, an <jats:sup>111<\/jats:sup>In\u2010chloride egg meal (300\u2003kcal) was ingested, and postprandial gastric volume and emptying were measured by SPECT. Symptom ratings using a visual analogue scale (fullness, nausea, bloating, abdominal pain, aggregate score) were obtained at baseline and 15, 30, 45, 60 and 75\u2003min postprandially. Group comparisons were performed using Mann\u2013Whitney rank sum test.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> There were no statistically significant differences in gastric volume or emptying in the two groups. However, there was a borderline increase in gastric volume with rabeprazole compared with placebo. Rabeprazole treatment reduced aggregate postprandial symptoms, particularly fullness, 30\u2003min after the meal (<jats:italic>P<\/jats:italic>\u2003=\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In healthy participants, rabeprazole, 20\u2003mg b.d., did not significantly change gastric emptying, but reduced symptoms and had a borderline effect on gastric volume postprandially. The mechanism of reduced postprandial symptoms with a PPI requires further study.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03102.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T08:25:28Z","timestamp":1158049528000},"page":"1037-1043","source":"Crossref","is-referenced-by-count":18,"title":["Effect of a proton pump inhibitor on postprandial gastric volume, emptying and symptoms in healthy human subjects: a pilot study"],"prefix":"10.1111","volume":"24","author":[{"given":"A. B. M.","family":"GRUDELL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"CAMILLERI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"BURTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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