{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:08:39Z","timestamp":1760954919196},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T00:00:00Z","timestamp":1160352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Published <jats:italic>in\u00a0vitro<\/jats:italic> and animal <jats:italic>in\u00a0vivo<\/jats:italic> studies have demonstrated that cyclo\u2010oxygenase\u20102 plays an important role during oesophageal adenocarcinogenesis. However, the extent to which these studies are directly relevant to events in the human lower oesophagus is questionable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To perform a systematic review of all available human studies that have evaluated levels of cyclo\u2010oxygenase\u20102 expression during the progression from Barrett's metaplasia to oesophageal adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed to identify all studies which qualitatively or quantitatively assessed cyclo\u2010oxygenase\u20102 protein or gene expression in either Barrett's, dysplastic or adenocarcinoma tissue in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 27 studies met the inclusion criteria. There was general agreement that cyclo\u2010oxygenase\u20102 was either absent or very weakly expressed in normal oesophageal squamous mucosa, but considerable disagreement regarding the presence of cyclo\u2010oxygenase\u20102 in Barrett's and low\u2010grade dysplasia. All studies agreed that high\u2010grade dysplasia and adenocarcinoma expressed cyclo\u2010oxygenase\u20102 to some extent although levels varied considerably between tissue samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is conflicting evidence in the literature for cyclo\u2010oxygenase\u20102 playing an important role in early oesophageal adenocarcinogenesis. Other non\u2010cyclo\u2010oxygenase\u20102 targets may account for the epidemiological data supporting the use of non\u2010steroidal anti\u2010inflammatory drugs in the chemoprevention of oesophageal adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03119.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T06:28:10Z","timestamp":1161152890000},"page":"1321-1331","source":"Crossref","is-referenced-by-count":14,"title":["Systematic review: cyclo\u2010oxygenase\u20102 in human oesophageal adenocarcinogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"S.","family":"MEHTA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"BODDY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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