{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:08:02Z","timestamp":1790935682901,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the incidence of death in patients diagnosed with Crohn's disease in Cardiff over 20\u2003years ago.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Cardiff database of patients with Crohn's disease contains data on all patients diagnosed there since 1934. Patients (394) diagnosed before 1 January 1985 were traced and their mortality status on 31 December 2004 was established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall standardized mortality ratio (SMR) was 1.29 (95% CI 1.12\u20131.45) and it has not significantly changed since the 1970s. SMR decreases with age, from 16.95 (95% CI 14.99\u201318.91) for patients aged 10\u201319\u2003years (although only one death) to 0.92 (95% CI 0.65\u20131.19) in those over 75\u2003years. Kaplan\u2013Meier analysis of age at death shows that patients diagnosed aged 10\u201326\u2003years have median age at death of 58\u2003years, those aged 27\u201352\u2003years of 66\u2003years, those aged 53\u201358\u2003years of 74\u2003years, and those over 59\u2003years of 79\u2003years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It shows a significantly raised SMR, not statistically changed since the 1970s and similar to other chronic conditions. Patients diagnosed younger have worse prognosis than those diagnosed later in life and a reduced life expectancy compared with the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03132.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T07:08:39Z","timestamp":1161155319000},"page":"59-65","source":"Crossref","is-referenced-by-count":26,"title":["Long\u2010term prognosis in Crohn's disease: an epidemiological study of patients diagnosed more than 20\u2003years ago in Cardiff"],"prefix":"10.1111","volume":"25","author":[{"given":"C.","family":"CANAVAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"ABRAMS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"HAWTHORNE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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