{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:04:28Z","timestamp":1793642668463,"version":"4.5.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Over\u2010the\u2010counter histamine\u20102 receptor antagonists, antacids and alginate\/antacids are commonly used for gastro\u2010oesophageal reflux disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To conduct a systematic review and meta\u2010analysis of related treatment trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic search and abstraction of randomized, placebo\u2010controlled trials conducted during 1972\u20132005. Study quality was measured by the Jadad score (0\u20135). Results were pooled using random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten trials (<jats:italic>n<\/jats:italic>\u2003=\u20033442, placebo\u2003=\u20032940; Jadad score 3.5) showed a higher response with histamine\u20102 receptor antagonists in regard to complete relief of heartburn, symptomatic improvement, and episodes requiring rescue antacids. The absolute benefit increase was 10\u201312% and relative benefit increase was 19\u201341%. Four trials (<jats:italic>n<\/jats:italic>\u2003=\u2003578, placebo\u2003=\u2003577; Jadad score 3.5) showed a trend in favour of antacids in symptomatic improvement (absolute benefit increase 8%, 95% CI: 0\u201316%; relative benefit increase 0.11) and requirement of rescue antacids (OR 0.70, 95% CI: 0.59\u20130.84). Four trials (<jats:italic>n<\/jats:italic>\u2003=\u2003146, placebo\u2003=\u2003138; Jadad score 3.8) found alginate\/antacid combination superior to placebo in symptomatic improvement (absolute benefit increase 26%, 95% CI: 12%\u201341%, relative benefit increase 0.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over\u2010the\u2010counter medications are effective in treating symptomatic gastro\u2010oesophageal reflux disease. Compared with the placebo response, which ranged between 37% and 64%, the relative benefit increase was up to 41% with histamine\u20102 receptor antagonists, 60% with alginate\/antacid combinations, and 11% with antacids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03135.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T07:08:39Z","timestamp":1161155319000},"page":"143-153","source":"Crossref","is-referenced-by-count":69,"title":["Meta\u2010analysis: the efficacy of over\u2010the\u2010counter gastro\u2010oesophageal reflux disease therapies"],"prefix":"10.1111","volume":"25","author":[{"given":"T.","family":"TRAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"LOWRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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