{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:23:47Z","timestamp":1792700627745,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Serum antinuclear antibodies giving the \u2018multiple nuclear dots\u2019 or the \u2018rim\u2010like\/membranous\u2019 patterns are frequently detected by indirect immunofluorescence on HEp\u20102 cells in patients with primary biliary cirrhosis.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To assess the accuracy of multiple nuclear dot and rim\u2010like\/membranous antinuclear antibodies for the diagnosis of primary biliary cirrhosis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sera from 4371 consecutive patients referred to our laboratory were analysed under code for antinuclear antibodies testing by indirect immunofluorescence on HEp\u20102 cells.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Review of the clinical records of the 4371 patients allowed identification of 101 patients with antimitochondrial antibody\u2010positive primary biliary cirrhosis and 22 with antimitochondrial antibody\u2010negative variant. Multiple nuclear dot and\/or rim\u2010like\/membranous patterns were found in 59 (1.3%) of the 4371 patients: 31 antimitochondrial antibody\u2010positive primary biliary cirrhosis, 17 antimitochondrial antibody\u2010negative primary biliary cirrhosis and 11 non\u2010primary biliary cirrhosis. The specificity for primary biliary cirrhosis of both the antinuclear antibodies pattern was 99%. Positive predictive value and likelihood ratio for a positive test were 86% (95% CI: 72.7\u201394) and 221 (95% CI: 91.7\u2013544) for multiple nuclear dot, 79% (95% CI: 62.2\u201390.1) and 132 (95% CI: 56.8\u2013312.7) for rim\u2010like\/membranous, respectively.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Multiple nuclear dot and rim\u2010like\/membranous antinuclear antibodies are rare findings. Their positivity strongly suggests the diagnosis of primary biliary cirrhosis, irrespective of antimitochondrial antibody status. The high specificity for primary biliary cirrhosis makes them a useful diagnostic tool especially in antimitochondrial antibody\u2010negative patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2006.03172.x","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T19:28:23Z","timestamp":1164742103000},"page":"1575-1583","source":"Crossref","is-referenced-by-count":72,"title":["Antinuclear antibodies giving the \u2018multiple nuclear dots\u2019 or the \u2018rim\u2010like\/membranous\u2019 patterns: diagnostic accuracy for primary biliary cirrhosis"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"GRANITO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"MURATORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"MURATORI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"PAPPAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"CASSANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"WORTHINGTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"GUIDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"FERRI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"DE MOLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"LENZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"CHAPMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. B.","family":"BIANCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)80033-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916321"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07257.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036558"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007185"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310004876"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91246-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(94)95333-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230512"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00033-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080438"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160121"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01719.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02332.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5984"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1373\/49.1.7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290126"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.4.440"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.11.813"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250507"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10446670410001722113"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20907"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/cgh.2003.50014"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.002"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007184"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310008412"},{"key":"e_1_2_6_29_2","first-page":"1135","article-title":"Clinical significance of different antinuclear antibodies patterns in the course of primary biliary cirrhosis","volume":"43","author":"Remmel T","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310008746"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2006.03172.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2006.03172.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T13:42:40Z","timestamp":1693489360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2006.03172.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,28]]},"references-count":29,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2036.2006.03172.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03172.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,28]]}}}