{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:55:33Z","timestamp":1773323733418,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p> <jats:italic>Helicobacter pylori<\/jats:italic> is recognized as one of the most significant risk factors for gastric cancer, and <jats:italic>H. pylori<\/jats:italic> eradication has been proposed as a possible primary chemo\u2010preventive strategy to reduce gastric cancer incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the available evidence on the efficacy of <jats:italic>H. pylori<\/jats:italic> eradication in the prevention of gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Epidemiological, observational and interventional studies, as well as decisional models, were taken into account in this review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Large\u2010scale epidemiological studies clearly link <jats:italic>H. pylori<\/jats:italic> infection with non\u2010cardia gastric cancer. Current evidence suggests that, in a subpopulation of treated subjects, <jats:italic>H. pylori<\/jats:italic> eradication prevents the progression of preneoplastic lesions. Studies that have attempted to evaluate the effect of <jats:italic>H. pylori<\/jats:italic> eradication on the incidence of gastric cancer have not provided definitive answers. <jats:italic>H. pylori<\/jats:italic> eradication seems to reduce the incidence of gastric cancer in patients without baseline precancerous gastric lesions. Decisional models suggest that <jats:italic>H. pylori<\/jats:italic> screening could be cost\u2010effective, but there is not yet sufficient evidence to support the setting up of a general screening programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> <jats:italic>Helicobacter pylori<\/jats:italic> eradication is a plausible intervention for gastric cancer prevention; however, it seems to be relevant in only a subset of subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2006.03183.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T11:54:13Z","timestamp":1279886053000},"page":"133-141","source":"Crossref","is-referenced-by-count":88,"title":["Systematic review: <i>Helicobacter pylori<\/i> eradication for the prevention of gastric cancer"],"prefix":"10.1111","volume":"25","author":[{"given":"L.","family":"FUCCIO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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